PMID: 8590550Nov 1, 1995Paper

Insulin resistance is not exhibited by advanced chronic obstructive pulmonary disease patients

Clinical Physiology
P JakobssonH von Schenck

Abstract

We have previously reported increased blood glucose concentrations and skeletal muscle glycogen depletion in severe COPD patients with chronic respiratory failure. In order to see if insulin resistance exists in severe COPD, we investigated nine patients with advanced COPD with chronic hypoxaemia and seven healthy control subjects of similar age, using the euglycaemic hyperinsulinaemic glucose clamp technique. We could not demonstrate a subnormal intravenous glucose requirement in response to insulin when maintaining euglycaemia in the COPD patients with chronic hypoxaemia. This indicates that the net metabolism of glucose in COPD patients with chronic hypoxaemia is not resistant to insulin.

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Citations

Aug 7, 2002·International Journal of Cardiology·Annemie M W J Schols
Oct 22, 2011·Journal of Applied Physiology·Christina C KaoFarook Jahoor
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·A M ScholsE F Wouters
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·E C CreutzbergE F Wouters
Sep 29, 2004·Diabetes Care·Jamal S RanaCarlos A Camargo
Sep 5, 2018·Journal of Cachexia, Sarcopenia and Muscle·Magdalena DziegalaEwa Jankowska
Aug 6, 2015·The American Journal of Chinese Medicine·Yi-Min LiLu-Ping Qin
Feb 13, 2001·American Journal of Physiology. Endocrinology and Metabolism·S L SchiffelersA M Schols

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