Insulin resistance relates to microvascular reactivity 23 years after preeclampsia

Microvascular Research
Julia J SpaanLouis L H Peeters

Abstract

Preeclampsia, an endothelial disorder of pregnancy, is associated with an increased risk on cardiovascular diseases. Cardiovascular risk factors may mediate vascular dysfunction both during pregnancy but also later in life. This study aims to investigate microvascular reactivity, and its relationship with several cardiovascular risk factors, in women with a history of preeclampsia and controls. In this cross-sectional study we compared women with a history of preeclampsia (PE, n=22) with women with uneventful pregnancies only (CON, n=29) 23 years after their first delivery. Participants were matched for BMI, age and date of delivery. We assessed blood concentrations of fasting glucose, HbA1c, insulin, (total, HDL-, LDL-) cholesterol, triglycerides and CRP. Endothelial function was assessed by measurement of skin microcirculatory blood flow by Laser Doppler flowmetry at the dorsal and ventral site of the finger during post-occlusive reactive hyperemia (PORH). PE had higher fasting insulin levels and HOMA-IR compared with CON. The PORH response was similar in both groups. The area under the curve of PORH correlated with insulin and HOMA-IR at both sites, with BMI, triglycerides at the dorsal site and with CRP at the ventral site ...Continue Reading

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Citations

Aug 16, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Eva ÖstlundThomas Kahan
Dec 13, 2012·Obstetrical & Gynecological Survey·Wietske HermesChristianne J M de Groot
Jun 13, 2015·Journal of Women's Health·Sanne VisserChristianne J M De Groot
Sep 13, 2017·European Journal of Preventive Cardiology·T Katrien J GroenhofA Titia Lely
Oct 17, 2012·Hypertension·Julia SpaanMark Brown
Nov 3, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Asako MitoMichihiro Kitagawa
Jul 19, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·I D GallosM Vatish
Apr 25, 2015·Journal of Hypertension·Nick Anim-NyamePhilip J Steer
Dec 16, 2020·American Journal of Perinatology·Logan C BarrGraeme N Smith
Jan 23, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Logan C BarrGraeme N Smith

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