Insulin resistance: The linchpin between prediabetes and cardiovascular disease

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Martin R SalazarG M Reaven

Abstract

The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascular disease prevention. Fasting plasma glucose concentrations defined participants as having normal fasting plasma glucose (fasting plasma glucose <5.6 mmol/L) or prediabetes mellitus (fasting plasma glucose ⩾ 5.6 and <7.0 mmol/L). The tertile of prediabetes mellitus subjects with the highest fasting plasma insulin concentration was classified as insulin resistant. Baseline cardiovascular disease risk factors were accentuated in prediabetes mellitus versus normal fasting glucose, particularly in prediabetes mellitus/insulin resistant. In 2012, 86% of the sample were surveyed again, and the crude incidence for cardiovascular disease was higher in subjects with prediabetes mellitus versus normal fasting glucose (13.7 vs 6.0/100 persons/10 years; age- and sex-adjusted hazard ratio = 1.88, p = 0.052). In prediabetes mellitus, the crude incidences were 22.9 versus 9.6/100 persons/10 years in insulin resistant versus non-i...Continue Reading

References

Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·J YipG M Reaven
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·F S FacchiniG M Reaven
Aug 13, 2003·Current Atherosclerosis Reports·Gerald M Reaven
May 13, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Martin R SalazarGerald M Reaven
Jan 17, 2014·JAMA : the Journal of the American Medical Association·Anna M SteeleAndrew T Hattersley

❮ Previous
Next ❯

Citations

Jul 20, 2016·Acta Diabetologica·Itahisa Marcelino RodríguezAntonio Cabrera de León
Mar 29, 2019·The Cochrane Database of Systematic Reviews·Siew S LimLisa J Moran
Dec 12, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·May YangSandra A Tsai
Sep 22, 2018·The Journal of Clinical Endocrinology and Metabolism·Ibiye OweiSam Dagogo-Jack
Feb 9, 2019·Cardiovascular Diabetology·Damilola D AdingupuAnn-Cathrine Jönsson-Rylander
Apr 13, 2017·Cardiovascular Diabetology·Judith van HaareMarc van Bilsen
Feb 26, 2021·Journal of Cardiovascular Translational Research·Ye-Shi ChenKai Yin

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.