PMID: 8591704Aug 1, 1995Paper

Insulin restores fatty acid composition earlier in liver microsomes than erythrocyte membranes in streptozotocin-induced diabetic rats

Diabetes Research and Clinical Practice
C S ShinH K Min

Abstract

Alterations of fatty acid composition have been observed in a number of tissues in both experimental and human diabetes. Suppression of delta 6 desaturase in the liver, a key enzyme of fatty acid desaturation, has been reported to be responsible for these phenomena. We measured the fatty acid composition of the liver and the erythrocytes, and examined delta 6 desaturase activities to compare the effect of short-term insulin therapy on the tissues with and without delta 6 desaturase, ie., the liver and the erythrocytes using streptozotocin (STZ)-induced diabetic rats. Linoleic (P < 0.05), palmitic (P < 0.01) and docosahexaenoic (DHA) acid (P < 0.01) were higher and arachidonic (P < 0.01) and oleic acid (P < 0.01) were lower in the liver microsomes of diabetic rats when compared to those in control rats. These alterations were partly reversed with insulin treatment. In the erythrocyte membrane, linoleic (P < 0.01) and stearic acid (P < 0.05) were higher, and palmitic (P < 0.05), palmitoleic (P < 0.01), and arachidonic acid (P < 0.01) were lower in diabetic rats. In contrast to the case of the liver microsomes, however, these alterations were persistently observed after 48 h of insulin treatment. The activities of delta 6 desatura...Continue Reading

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Citations

Apr 28, 1999·Free Radical Biology & Medicine·N TraversoU M Marinari
Aug 6, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·K GhebremeskelM A Crawford
Sep 28, 1999·Clinical and Experimental Pharmacology & Physiology·M NandakumaranT N Sugathan
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Feb 27, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T DecsiGy Soltész
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Jul 20, 2010·Journal of Autoimmunity·Panayiotis G Vlachoyiannopoulos, John G Routsias
Feb 3, 2005·International Immunopharmacology·Enrico Maria ZardiAntonella Afeltra
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Jun 21, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kasiappan RaviSorimuthu Subramanian

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