Insulin secretion abnormalities in exocrine pancreatic sufficient cystic fibrosis patients

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Jamie L WooldridgeDeborah A Elder

Abstract

The aim of this study is to assess insulin secretion in pediatric cystic fibrosis (CF) patients with exocrine pancreatic sufficiency. Glucose and insulin responses during an oral glucose tolerance test (OGTT) were measured in 146 CF patients. Patients were divided into exocrine sufficient (CF-PS) and insufficient (CF-PI) groups based on pancreatic enzyme usage and fecal elastase. A reference group included healthy, non-diabetic subjects. All CF groups showed reduced insulin secretion as measured by insulinogenic index. The CF-PS patients had normal glucose tolerance. There was a direct correlation between BMI z-score and insulin area under the curve. Patients with CF have reduced insulin secretion during an OGTT regardless of exocrine pancreatic status. The abnormal insulin secretion in all CF patients may predispose them for glucose intolerance, particularly when challenged by inflammation, infection, or nutritional deficiency. In addition, the diminished insulin secretion may contribute to increased catabolism. Lastly, the CF-related diabetes (CFRD) screening guidelines should be followed by all CF patients regardless of pancreatic status.

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Citations

Jun 13, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Marie-Angela SchnyderChristoph Schmid
Jul 18, 2017·Pediatric Pulmonology·Amir Moheet, Antoinette Moran
Feb 6, 2019·The Journal of Endocrinology·Anna EdlundLena Eliasson
Apr 20, 2018·JCI Insight·Nathaniel J HartAlvin C Powers
Jun 14, 2019·Clinical Medicine Insights. Endocrinology and Diabetes·Ryan KelseyCatriona Kelly
Dec 3, 2020·PloS One·Mauricio Di FulvioLydia Aguilar-Bryan
Mar 5, 2021·Frontiers in Cell and Developmental Biology·Junzhong GuYuchun Gu
Aug 5, 2021·Clinical Medicine Insights. Endocrinology and Diabetes·Efraim WestholmLena Eliasson
Aug 17, 2021·Frontiers in Endocrinology·Lise CoderreSylvie Lesage

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