Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study.

Diabetes
Muhammad A Abdul-GhaniRalph A DeFronzo

Abstract

This study was conducted to observe changes in insulin secretion and insulin action in subjects with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). A total of 319 subjects were studied with an oral glucose tolerance test (OGTT). Fasting plasma glucose and insulin concentrations were measured at baseline and every 30 min during the OGTT. Fifty-eight subjects also received a euglycemic-hyperinsulinemic clamp. Insulin sensitivity was calculated as the total glucose disposal (TGD) during the last 30 min of the clamp. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from fasting plasma glucose and insulin concentrations. Subjects with IFG had TGD similar to normal glucose-tolerant subjects, while subjects with IGT and combined IFG/IGT had significantly reduced TGD. HOMA-IR in subjects with IFG was similar to that in subjects with combined IFG/IGT and significantly higher than HOMA-IR in subjects with IGT or NGT. Insulin secretion, measured by the insulinogenic index (DeltaI(0-30)/DeltaG(0-30)) and by the ratio of the incremental area under the curve (AUC) of insulin to the incremental AUC of glucose (0-120 min), was reduced to the same extent in all three glucose-intolerant groups....Continue Reading

Associated Clinical Trials

References

Sep 1, 1979·The American Journal of Physiology·R A DeFronzoR Andres
Sep 7, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·M J DaviesA C Burden
Mar 22, 2001·Journal of Diabetes and Its Complications·F Guerrero-Romero, M Rodríguez-Morán
Oct 27, 2001·Diabetes Care·E EschwègeUNKNOWN Paris Prospective Study
Jan 30, 2002·Diabetes·Timon W van HaeftenJohn E Gerich
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N UnwinK G M M Alberti
Oct 1, 1956·The American Journal of Physiology·R STEELEN ALTSZULER
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Dec 11, 2003·Diabetologia·A GastaldelliUNKNOWN San Antonio metabolism study
Aug 17, 2004·The Medical Clinics of North America·Ralph A DeFronzo

❮ Previous
Next ❯

Citations

Oct 18, 2011·Obesity Surgery·Jonathan FooRichard Strawson Stubbs
Jun 6, 2009·Current Diabetes Reports·Muhammad A Abdul-Ghani, Ralph A DeFronzo
Apr 29, 2010·Current Diabetes Reports·Devjit Tripathy, Alberto O Chavez
Sep 21, 2011·The British Journal of Nutrition·Jennie WickenbergJoanna Hlebowicz
Jun 30, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C C M MoorsG H Goossens
Oct 4, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S RomeoM G Baroni
Mar 25, 2011·The New England Journal of Medicine·Ralph A DeFronzoUNKNOWN ACT NOW Study
Aug 8, 2013·Diabetes Technology & Therapeutics·Francine D SalinitriLinda A Jaber
Dec 4, 2012·Clinical and Experimental Pharmacology & Physiology·Ting-Ting DuXue-Feng Yu
Oct 11, 2007·Diabetes, Obesity & Metabolism·T P J Solomon, A K Blannin
Oct 18, 2007·Diabetes, Obesity & Metabolism·J Rosenstock
May 28, 2011·Diabetes, Obesity & Metabolism·M FernandezR A DeFronzo
Jan 10, 2012·Diabetes, Obesity & Metabolism·N J van der ZijlM Diamant
Aug 20, 2012·Journal of Diabetes Investigation·Rie MitsuiNobuya Inagaki
Aug 19, 2010·American Journal of Physiology. Endocrinology and Metabolism·Edward LinNana Gletsu-Miller
Jun 5, 2008·American Journal of Physiology. Endocrinology and Metabolism·Leigh PerreaultRobert H Eckel
Jul 31, 2009·BMC Endocrine Disorders·Ralph A DefronzoDevjit Tripathy
Feb 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Anna M G Cali'Sonia Caprio
Apr 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Thomas ReinehrChristian L Roth
Mar 12, 2009·The Journal of Clinical Endocrinology and Metabolism·Samuel Dagogo-JackGunjan Tykodi
Feb 20, 2010·Journal of Strength and Conditioning Research·Melody D PhillipsKimberly A Hubing
Jan 1, 2011·The Review of Diabetic Studies : RDS·Mohsen Janghorbani, Masoud Amini
Sep 23, 2010·Vascular Health and Risk Management·Curtis TriplittRalph A DeFronzo

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.