Insulin secretion and metabolism during the perinatal period in the rat. Evidence for a placental role in fetal hyperinsulinemia

The Journal of Clinical Investigation
F R Sodoyez-GoffauxC J De Vos

Abstract

To better understand why plasma immunoreactive insulin (IRI) concentration is high in the rat fetus during the last 3 d of gestation and why fetal hyperinsulinemia abruptly subsides after birth, insulin secretion and metabolic clearance rates were estimated in fetuses and nursed pups. Intravenously injected [(125)I]monoiodoinsulin was cleared from the plasma of prematurely delivered pups at least as rapidly as from that of 7- to 10-d-old pups, suggesting that fetal hyperinsulinemia is not a result of slow clearance of the hormone. The fetal liver bound 35% of the injected label within 3 min, and binding was saturable. The uptake of radioactivity by the fetal kidney was nonsaturable and much lower than that of adult rat kidney. Isolated fetal islets were already reactive to glucose on the 19th d of gestation. Pancreatic insulin secretory capacity was estimated by measuring (a) the insulin release of isolated islets incubated in the presence of 2.8 mM glucose, (b) the insulin content of the same islets, and (c) the total insulin extracted from the pancreas, using the formula (a x c)/b. 2 d before birth, the pancreatic insulin secretory capacity was high, accounting for fetal hyperinsulinemia. It was even higher after birth, not a...Continue Reading

References

Feb 1, 1979·Diabetologia·F Sodoyez-GoffauxP P Foà
Jul 1, 1972·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E Heinze, J Steinke
Sep 1, 1974·The Journal of Endocrinology·A Kervran, J R Girard
Nov 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K Asplund
Jan 1, 1972·Biology of the Neonate·N M Cohen, R C Turner
Mar 1, 1971·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J M FelixR Jacquot
Jun 1, 1967·The Journal of Clinical Investigation·M J Chamberlain, L Stimmler
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE

❮ Previous
Next ❯

Citations

Jun 30, 1986·Toxicology and Applied Pharmacology·S A Chow, L J Fischer
Aug 6, 2011·Biological Reviews of the Cambridge Philosophical Society·Matthew J HydePaul R Kemp
Nov 1, 1982·Journal of Cellular Physiology·N A SchroedlR L McCarl
Jun 1, 2000·Metabolism: Clinical and Experimental·K NodaN Toyoda
Dec 30, 2014·BMJ Case Reports·Gabrielle Katrine Welle-StrandEdle Ravndal
Mar 11, 1983·The American Journal of Physiology·J L IzzoF Kleiman
Apr 1, 1983·The American Journal of Physiology·H P AmmonE J Verspohl
Dec 1, 1985·Metabolism: Clinical and Experimental·E A CatlinW Oh
May 31, 1982·Biochemical and Biophysical Research Communications·M E BembenekJ P Liberti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.