Insulin secretion and sensitivity in black versus white prepubertal healthy children

The Journal of Clinical Endocrinology and Metabolism
Silva A ArslanianJ E Janosky

Abstract

We had previously demonstrated greater insulin secretion and lower insulin sensitivity in black pubertal adolescents compared with whites. This study aimed to investigate whether similar black/white differences are present in the prepubertal period or are characteristics of the pubertal period. Twelve black and 11 white healthy prepubertal children, matched for age, body mass index, and Tanner I pubertal development, underwent a 2-h hyperglycemic clamp (225 mg/dL). Physical fitness was assessed by maximal oxygen consumption (VO2max) measurement during graded bicycle ergometry, and resting energy expenditure was measured by indirect calorimetry after overnight fast. Fasting and first phase insulin concentrations were higher in blacks than in whites [14.7 +/- 1.3 vs. 10.4 +/- 1.2 (P = 0.02) and 76.9 +/- 6.8 vs. 52.1 +/- 6.4 microU/mL (P = 0.016)]. There were no differences in second phase insulin levels and insulin sensitivity index. Both maximal oxygen consumption (VO2max) and resting energy expenditure were lower in black children, whereas insulin-like growth factor I was higher. After controlling for these differences, race contributed significantly to basal insulin, but not to first phase insulin. In summary, previously repor...Continue Reading

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Citations

May 25, 2004·Archives of Disease in Childhood·J WeillP Froguel
May 25, 2004·Archives of Disease in Childhood·A R GatradA Sheikh
Sep 11, 2008·The Journal of Clinical Endocrinology and Metabolism·Krista CasazzaBarbara A Gower
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Sep 1, 2009·Endocrinology and Metabolism Clinics of North America·Ebe D'AdamoSonia Caprio
Mar 27, 2007·The Journal of Pediatrics·Mary M Duck, Robert P Hoffman
Mar 3, 2007·Journal of Diabetes and Its Complications·Regina Cintra Querino da SilvaSérgio Atala Dib
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Jun 1, 2011·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Donna Spruijt-Metz
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Apr 24, 2014·Pediatric Diabetes·Rebecca J Brown, Jack A Yanovski
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Nov 30, 2019·Journal of Diabetes Research·M LadwaL M Goff

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