Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects. Assessments using hyperglycemic glucose clamps and oral glucose tolerance tests

Diabetes Care
T W van HaeftenD W Erkelens

Abstract

To assess insulin secretion in normal glucose-tolerant Caucasian first-degree relatives of type 2 diabetes subjects and in matched normal glucose-tolerant control subjects and to compare insulin secretion as assessed using a hyperglycemic glucose clamp with insulin secretion as assessed using an oral glucose tolerance test (OGTT). Twenty-one first-degree relatives of type 2 diabetic subjects and 21 control subjects without a family history of type 2 diabetes, who were matched for sex, age, BMI, waist-to-hip ratio, and aerobic capacity, underwent a hyperglycemic glucose clamp (10 mmol/l, 180 min). An OGTT (75 g glucose in 300 ml water) was also performed. First-phase insulin release (plasma insulin, 0-10 min) was not different (multiple analysis of variance [MANOVA]: F = 2.63, P = 0.11). Second-phase insulin release was lower (MANOVA: F = 4.18, P = 0.047). Separate analyses of variance showed decreased plasma insulin levels from 120 min onward (all P < 0.05), decreasing to geometric mean (95% CI) levels of 330 (270-402) and 462 (366-582) pmol/l at 180 min in relatives and control subjects, respectively. The insulin sensitivity index (ISI) as assessed using a hyperglycemic clamp was not different between the two groups. Mean +/- ...Continue Reading

Citations

Apr 1, 1979·Comprehensive Therapy·R W Turkington
Jan 1, 2003·Human Immunology·Elva Perez-LuqueClara Gorodezky
Nov 15, 2002·Molecular and Cellular Endocrinology·Timon W van Haeften
May 31, 2001·European Journal of Clinical Investigation·M StumvollH Häring
Feb 28, 2001·Diabetes, Obesity & Metabolism·J E Gerich
Jul 4, 2009·Osteopathic Medicine and Primary Care·Ramachandra Rahul V Chemitiganti, Craig W Spellman
Dec 17, 2011·The Journal of Clinical Endocrinology and Metabolism·Carlos LorenzoSteven M Haffner
Jan 26, 2012·Indian Journal of Endocrinology and Metabolism·Edavan P PraveenAriachery C Ammini
May 30, 2014·Endocrine Journal·Jiunn-Diann LinYen-Lin Chen
Oct 26, 2010·Journal of Psychosomatic Obstetrics and Gynaecology·Dolores CannellaAlan Monheit
Apr 13, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·C E EzenwakaN V Offiah
Jan 14, 2012·The Journal of Pediatrics·Deborah A ElderDavid A D'Alessio
May 29, 2004·Obesity Research·Braxton D MitchellMohammed F Saad
Apr 17, 2004·European Journal of Clinical Investigation·T W van Haeften, Th B Twickler
Dec 17, 2009·Metabolism: Clinical and Experimental·Jiunn-Diann LinDee Pei
Jul 3, 2002·Biochemical Pharmacology·Ingo Rustenbeck
Mar 31, 2015·International Journal of Endocrinology·Jiunn-Diann LinYen-Lin Chen
Nov 25, 2004·Diabetes·J-L Chiasson, Rémi Rabasa-Lhoret
Jan 30, 2002·Diabetes·Michael StumvollHans-Ulrich Häring
Jan 30, 2004·Diabetes·Leen M 't HartTimon W van Haeften
Mar 2, 2002·Diabetes·Leen M 't HartTimon W van Haeften
Nov 13, 2009·Diabetes Care·Muhammad A Abdul-Ghani, Ralph A DeFronzo
Feb 11, 2015·PloS One·Jinping ZhangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Jun 16, 2016·Metabolic Syndrome and Related Disorders·Jiunn-Diann LinYen-Lin Chen
Mar 17, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A L MendesW P Pimenta
Mar 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W P PimentaJ E Gerich
Nov 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jamileh MovassatBernard Portha

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