Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus

The Journal of Clinical Investigation
H S SeltzerM T Brennan

Abstract

Insulin secretory responses to paired intravenous and oral glucose loads were determined in 38 nonobese individuals classified as normal (nondiabetic) subjects, "mild" diabetics (fasting blood glucose below 105 mg per 100 ml), or "moderate" diabetics (fasting glucose below 192 mg per 100 ml). Studies were also performed in 29 obese persons who were similarly grouped. The intravenous load was given to assess the alacrity of hormonal release after glycemic stimulus, and the oral glucose to determine how the speed of initial insulinogenesis modifies the disposition of ingested carbohydrate. In the nonobese group, normal subjects responded to massive hyperglycemia after rapid injection of glucose with immediate and maximal outpouring of insulin, in contrast to a desultory insulinogenic response in patients with mild diabetes, and no initial response at all in moderate diabetics. During oral glucose tolerance tests, the much faster clearance of blood sugar in nondiabetic subjects was actually associated with lower absolute insulin output than was found in mildly diabetic patients, since the latter exhibited delayed hyperinsulinemia in concert with prolonged hyperglycemia. Moderate diabetics never showed excessive insulin release des...Continue Reading

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References

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Citations

Jul 1, 1992·Diabetes/metabolism Reviews·W Creutzfeldt, M Nauck
Aug 31, 1973·Zeitschrift Für Kinderheilkunde·B Weber, B Neumann
Aug 27, 1973·Pflügers Archiv : European journal of physiology·A J BenadéN B Strydom
Nov 29, 1977·Archiv für Gynäkologie·B R Muck, G Hommel
Dec 1, 1973·The American Journal of Digestive Diseases·W GrabnerP Strigl
Oct 1, 1973·Diabetologia·M J Smith, M R Hall
Dec 15, 1977·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H DörflerN Zöllner
Jul 1, 1981·Acta diabetologica latina·N RiccioniR Navalesi
Apr 1, 1981·Acta diabetologica latina·R KikkawaW Stauffacher
Jan 1, 1971·The American Journal of Digestive Diseases·R WhangH S Seltzer
Jan 1, 1986·Diabetologia·M NauckW Creutzfeldt
Jan 1, 1978·Acta diabetologica latina·R Luft, S Efendić
Apr 1, 1988·Acta diabetologica latina·R TorellaD Giugliano

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