Insulin selectively downregulates alpha2-adrenoceptors in the arcuate and dorsomedial nucleus

Brain Research Bulletin
B E LevinD P Lattemann

Abstract

Intracerebroventricular infusion of insulin (2 mU/ day) produced selective downregulation of 3H-paraminoclonidine binding to alpha2-adrenoceptors in the hypothalamic arcuate (14%) and dorsomedial (19%) nuclei out of 16 forebrain areas in Wistar rats. Binding of 3H-prazosin to alpha1-adrenoceptors was unaffected. This is in keeping with the known effect of insulin on catecholamine and neuropeptide Y metabolism in these brain regions that play an important role in energy homeostasis.

References

Jun 1, 1992·Endocrinology·M W SchwartzD P Figlewicz
Jun 1, 1995·Behavioral Neuroscience·M ChavezS C Woods
Jan 1, 1993·Brain Research Bulletin·D P FiglewiczI Ocrant

❮ Previous
Next ❯

Citations

Sep 8, 2012·Molecular Neurobiology·Rasoul GhasemiAbolhassan Ahmadiani
Jul 29, 2000·Physiology & Behavior·S C ThompsonD P Figlewicz
Jul 11, 2001·Neuroscience and Biobehavioral Reviews·C R Park
Sep 23, 1998·Brain Research Bulletin·B E Levin, A A Dunn-Meynell
Jan 23, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christa M PattersonBarry E Levin
Sep 1, 2015·Molecular and Cellular Endocrinology·Jenny L Wilson, Pablo J Enriori
Jul 15, 2015·Journal of Intensive Care Medicine·F BilottaG Rosa
Oct 17, 2018·Canadian Journal of Physiology and Pharmacology·Shiba YousefvandAbbas Parham
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V A Boundy, A H Cincotta
May 8, 1999·The American Journal of Physiology·B E LevinV H Routh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.