Insulin Sensitivity and Glucose Homeostasis Can Be Influenced by Metabolic Acid Load

Nutrients
Lucio Della GuardiaHellas Cena

Abstract

Recent epidemiological findings suggest that high levels of dietary acid load can affect insulin sensitivity and glucose metabolism. Consumption of high protein diets results in the over-production of metabolic acids which has been associated with the development of chronic metabolic disturbances. Mild metabolic acidosis has been shown to impair peripheral insulin action and several epidemiological findings suggest that metabolic acid load markers are associated with insulin resistance and impaired glycemic control through an interference intracellular insulin signaling pathways and translocation. In addition, higher incidence of diabetes, insulin resistance, or impaired glucose control have been found in subjects with elevated metabolic acid load markers. Hence, lowering dietary acid load may be relevant for improving glucose homeostasis and prevention of type 2 diabetes development on a long-term basis. However, limitations related to patient acid load estimation, nutritional determinants, and metabolic status considerably flaws available findings, and the lack of solid data on the background physiopathology contributes to the questionability of results. Furthermore, evidence from interventional studies is very limited and th...Continue Reading

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Citations

Jan 2, 2019·International Journal of Molecular Sciences·Nicola Baldini, Sofia Avnet
Feb 13, 2020·International Journal of Molecular Sciences·Salvador HarguindeyJesús Devesa
Dec 10, 2020·The Journal of Nutrition·Jesús Francisco García-GavilánMonica Bulló
Nov 12, 2020·Nutrients·Joanna OstrowskaDorota Szostak-Węgierek
Oct 12, 2020·Biochemical Pharmacology·Bianca N QuadeRossana Occhipinti
Sep 10, 2021·Open Heart·James J DiNicolantonio, James H O'Keefe

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Methods Mentioned

BETA
X-ray
hormone-replacement therapy

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