Insulin Sensitivity and Testicular Function in a Cohort of Adult Males Suspected of Being Insulin-Resistant

Frontiers in Medicine
Patricio H ContrerasPilar Vigil

Abstract

A cohort of 141 males (18-80 yo, 42.9 ± 12.9) strongly suspected of being Insulin Resistant (IR) was prospectively studied by determining their insulin sensitivity (Pancreatic Suppression Test, PST) and testicular function (total testosterone and SHBG). The subjects were labeled as IR when the Steady State Plasma Glucose (SSPG) was ≥150 mg/dL and Non-Insulin Resistant (NIR) when SSPG was <150 mg/dl; similarly, the subjects were labeled as Hypogonadal (HYPOG) when total testosterone was ≤3.0 ng/mL and Eugonadal (EUG) when total testosterone was >3.0 ng/mL. Two out of three subjects turned out to be IR, while around one in four subjects were HYPOG. Contingency analysis indicated a significant interdependence between insulin resistance and hypogonadism (chi-square was 4.69, p = 0.0303). Age (>43 yo) predicted hypogonadism (AUROC 0.606, p = 0.0308). Twice as many HYPOG subjects were IR as compared with EUG subjects. Also, HYPOG subjects exhibited higher SSPG values as compared with EUG subjects. Statistically, neither Weight nor BMI predicted hypogonadism, while Waist Circumference (>110 cm) was only a mediocre predictor (AUROC 0.640, p = 0.009). SSPG (>224 mg/dL) on the other hand, was the best predictor of hypogonadism (AUROC 0.7...Continue Reading

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Citations

Sep 11, 2019·Andrology·M GrossmannA S Cheung
Nov 7, 2019·Journal of Endocrinological Investigation·A RanjanA Krishna
Oct 10, 2018·The Journal of Clinical Endocrinology and Metabolism·Patricio H Contreras, Pilar Vigil
May 30, 2019·Journal of the Endocrine Society·Patricio H ContrerasPilar Vigil
Mar 7, 2020·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Liong Boy KurniawanBudi Mulyono
May 17, 2021·Current Opinion in Pharmacology·Monica Caliber, Farid Saad

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