Insulin sensitivity in normal and diabetic cats

Journal of Feline Medicine and Surgery
J R FeldhahnG Martin

Abstract

Estimates of in vivo insulin sensitivity (S(I)) can be derived from minimal model analysis of a frequently sampled intravenous glucose tolerance test (FSIVGTT). Modification of the FSIVGTT by the injection of insulin allows insulin sensitivity to be measured in diabetics. To establish and compare reference values for insulin sensitivity in clinically normal and diabetic cats, we subjected 10 clinically normal cats and five diabetic cats to the insulin-modified FSIVGTT with minimal model analysis. Diabetic cats had a significantly lower insulin sensitivity than clinically normal cats (P<0.05). Mean insulin sensitivity in clinically normal cats was 3.22x10(-4)/min/microU/ml (range 1.71-5.23x10(-4)/min/microU/ml). In contrast, the mean insulin sensitivity in diabetic cats was 0.58x10(-4)/min/microU/ml (range 0.136-0.88x10(-4)/min/microU/ml), or approximately six times less insulin sensitive than clinically normal cats. Mean glucose effectiveness in clinically normal cats was 0.030/min (range 0.021-0.045/min). Mean glucose effectiveness in diabetic cats was 0.014/min (range 0.008-0.021/min). Our data demonstrate that insulin resistance is a feature of feline diabetes mellitus and that diabetic cats have a similar relative decrease ...Continue Reading

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Citations

May 20, 2005·American Journal of Veterinary Research·Nicole BennettMichael R Lappin
Jun 15, 2006·The Journal of Nutrition·Alexander J German
Dec 6, 2008·Veterinary Dermatology·Andrew D LoweThomas Graves
Jul 16, 2010·Journal of Animal Physiology and Animal Nutrition·R C BackusV C Biourge
Aug 6, 2013·New Zealand Veterinary Journal·C A O'LearyJ S Rand
Jun 6, 2020·Frontiers in Veterinary Science·Susan GottliebZiad Ramadan
May 5, 2006·Veterinary Pathology·P RoccabiancaM Caniatti
Jul 31, 2004·The Journal of Nutrition·Jacquie S RandRose Lederer
Sep 15, 2005·Journal of Animal Science·K H TreiberP A Harris
Jul 10, 2012·Journal of Diabetes Science and Technology·Margarethe Hoenig
Nov 21, 2001·Journal of Feline Medicine and Surgery·J R FeldhahnE Kinnaird
Sep 13, 2003·Journal of Animal Science·R M HoffmanP A Harris
Sep 3, 2009·Journal of the American Animal Hospital Association·Andrew D LoweDavid J Schaeffer
Jun 1, 2005·Journal of Feline Medicine and Surgery·D J AppletonG D Sunvold

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