Insulin sensitivity in relation to fat distribution and plasma adipocytokines among abusers of anabolic androgenic steroids

Clinical Endocrinology
Jon Jarløv RasmussenCaroline Kistorp

Abstract

Abuse of anabolic androgenic steroids (AAS) is prevalent among young men, but information regarding effects on insulin sensitivity and fat distribution is limited. The objective was to investigate insulin sensitivity in relation to fat distribution and adipocytokines among current and former AAS abusers compared with controls. Cross-sectional study among men involved in recreational strength training. Current and former AAS abusers (n=37 and n=33) and controls (n=30) volunteered from the community. We assessed insulin sensitivity by Matsuda index (oral glucose tolerance test). Using overnight fasting blood samples, adiponectin and leptin were measured. Body composition and fat distribution, including visceral adipose tissue (VAT), were assessed by dual energy X-ray absorptiometry. Current and former AAS abusers displayed lower Matsuda index than controls (%-difference (95%CI) from controls, -26% (-45; -1) and -39% (-55; -18)). Testosterone was markedly higher among current AAS abusers and subnormal among former AAS abusers compared with controls. Current AAS abusers displayed higher mean VAT than controls (388 (17) vs 293 (12) cm3 , P<.001) whereas body fat %, adiponectin and leptin concentrations were lower. In contrast, forme...Continue Reading

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Citations

Mar 19, 2019·European Journal of Sport Science·Georgios A ChristouKonstantinos A Christou
Jan 3, 2019·The Journal of Clinical Endocrinology and Metabolism·Daan M van VelzenMartin den Heijer
Jun 9, 2020·The Journal of Clinical Endocrinology and Metabolism·Jon J Rasmussen, Caroline Kistorp
Jun 17, 2020·Journal of the Endocrine Society·Jon J RasmussenCaroline Kistorp
Mar 5, 2020·Substance Abuse : Research and Treatment·Ingrid Amalia HavnesAstrid Bjørnebekk
Oct 6, 2020·Seminars in Thrombosis and Hemostasis·Johannes Jakobsen SidelmannCaroline Kistorp
Jan 6, 2021·Thrombosis and Haemostasis·Johannes Jakobsen SidelmannCaroline Kistorp
Apr 4, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Astrid BjørnebekkLars T Westlye
Mar 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Jon Jarløv RasmussenCaroline Kistorp
Jun 26, 2021·The World Journal of Men's Health·Giovanni CoronaMario Maggi
Dec 22, 2021·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Andrea Prestes NáculCristina Laguna Benetti-Pinto

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