Insulin sensitivity is impaired in heterozygous carriers of lipoprotein lipase deficiency

Diabetologia
B HölzlF Sandhofer

Abstract

Several studies have investigated the lipoprotein phenotype in heterozygous carriers of a defective lipoprotein lipase allele. We studied whether heterozygosity for lipoprotein lipase deficiency also affects glucose metabolism beyond its effect on plasma lipids. To address this question 85 heterozygous carriers of either a missense mutation (Gly188Glu) or a splice site mutation (C-->A in position -3 at the acceptor splice site of intron 6) in the LPL gene which both result in a catalytically inactive product were compared with 108 unaffected subjects from the same families. Carriers for one of these mutations had higher fasting insulin levels but only a trend towards increased fasting blood glucose concentrations could be detected. HOMA index values were significantly higher in carriers than in non-carriers. Furthermore, in carriers, a significantly higher BMI and a trend towards higher systolic and diastolic blood pressure were observed. Carriers also had significantly higher fasting triglycerides, lower HDL cholesterol, and lipoprotein lipase particles of smaller size, confirming previous reports. Among carriers, subjects with one rare allele of the SstI polymorphism in the apo CIII gene had significantly higher plasma trigly...Continue Reading

Citations

Oct 25, 2002·Diabetes/metabolism Research and Reviews
Jan 18, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·David M FlavellHugh E Montgomery
Oct 16, 2002·Current Cardiology Reports·John E Hokanson
Jul 30, 2009·European Journal of Human Genetics : EJHG·Cui XieMao Sheng Yang
Jan 11, 2012·Antioxidants & Redox Signaling·Nidhi ChaudharySamit Chattopadhyay
May 19, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Anna G McLeanMatthew P Doogue
Apr 21, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S W Rabkin
Nov 25, 2004·Metabolism: Clinical and Experimental·Enqi LiuJianglin Fan
Jul 27, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Osamu HanyuYoshifusa Aizawa
Mar 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Hong Wang, Robert H Eckel
Aug 8, 2018·United European Gastroenterology Journal·Nicolò de PretisLuca Frulloni
Jul 4, 2003·Current Opinion in Lipidology·Marek H Dominiczak
May 27, 2021·Bioscience Reports·Mingzhu LuoXuewei Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

© 2022 Meta ULC. All rights reserved