Insulin sensitivity of the large human adipocyte in vitro.

Diabetes
M B Davidson

Abstract

Adipose tissue from twelve normal-weight and ten obese subjects on weight-maintaining diets and nine obese subjects on hypocaloric diets was removed at surgery and incubated in vitro. Basal glucose oxidation correlated significantly (r = 0.68, p less than 0.005) with fat-cell diameter in subjects on weight-maintaining diets. This relationship was significantly altered (p less than 0.02) in subjects on calorie-restricted diets. In tissue from subjects on weight-maintaining diets, physiologic concentrations of insulin (25 muU./ml.) significantly increased glucose incorporation into carbon dioxide (p less than 0.005) and glycogen (p less than 0.001). Maximum insulin-stimulated glucose oxidation (increase over basal) was significantly enhanced (p less than 0.05) in tissue from obese subjects, whereas insulin-mediated glucose incorporation into glycogen was similar in controls and obese subjects on weight-maintaining diets. Insulin-stimulated glucose oxidation was imparied in tissue from subjects on hypocaloric diets although fat-cell diameter was similar to those of obese subjects on weight-maintaining diets. The effect of insulin on glucose incorporation into glycogen in isolated adipocytes was also studied. There was no correlati...Continue Reading

Citations

Jul 1, 1979·Acta diabetologica latina·B SchulzH Bibergeil
Oct 1, 1981·Journal of the Neurological Sciences·E MablyA J Hudson
Mar 4, 2015·Molecular and Cellular Biology·Jong In KimJae Bum Kim
Aug 1, 1982·The American Journal of Physiology·O PedersenH O Lindskov
Jan 1, 1993·The American Journal of Physiology·M B Davidson, D Garvey

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