Insulin sensitivity regulated by feeding in the conscious unrestrained rat

Canadian Journal of Physiology and Pharmacology
Martin G Latour, W Wayne Lautt

Abstract

Hepatic insulin sensitizing substance (HISS), a putative hormone released from the liver in response to insulin in fed animals, accounts for 50-60% of insulin action. HISS release is regulated by permissive control of the hepatic parasympathetic nerves. The objectives were to develop the rapid insulin sensitivity test (RIST) in conscious rats, and to assess the effects of anesthesia, atropine, feeding, and fasting on insulin action. The RIST index, expressed as milligrams glucose per kilogram body weight required to maintain euglycemia after a 50 mU/kg bolus of insulin, was similar in conscious and anesthetized rats (238.6+/-42.5 vs. 225.3+/-30.4 mg/kg). Atropine produced a 56% inhibition of insulin action in fed rats. After a 24 h fast, full HISS-dependent insulin resistance had developed as shown by a low RIST index that was not reduced further by atropine. Fasting caused a 10.5% decrease in insulin action per hour over six hours. HISS-dependent insulin resistance in 24-h fasted rats was reversed 4 h after re-feeding (90.9+/-12.3 vs. 204.5+/-30.5 mg/kg). We conclude that HISS-dependent and HISS-independent insulin action, as assessed by the RIST, is similar in conscious and pentobarbital-anesthetized rats. Pharmacological blo...Continue Reading

References

Apr 1, 1996·Journal of Pharmacological and Toxicological Methods·H XieW W Lautt
Oct 1, 1995·Journal of Autonomic Pharmacology·H Xie, W W Lautt
May 1, 1996·The American Journal of Physiology·H Xie, W W Lautt
Jul 17, 1999·The American Journal of Physiology·P Sadri, W W Lautt
Jun 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·W W LauttD J Legare

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Citations

Jul 3, 2010·The British Journal of Nutrition·Ricardo A AfonsoM Paula Macedo
Oct 2, 2012·The British Journal of Nutrition·Kawshik K ChowdhuryW Wayne Lautt
Mar 29, 2008·Metabolic Syndrome and Related Disorders·W Wayne Lautt
Mar 29, 2008·Metabolic Syndrome and Related Disorders·W Wayne LauttHeather Prieditis
Jun 19, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rogério Tavares RibeiroMaria Paula Macedo
Sep 1, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·W Wayne Lautt
Dec 18, 2008·Canadian Journal of Physiology and Pharmacology·Rita S PatarrãoM Paula Macedo
Feb 18, 2011·Canadian Journal of Physiology and Pharmacology·W Wayne LauttDallas J Legare
Jun 15, 2012·Canadian Journal of Physiology and Pharmacology·Ana B FernandesM Paula Macedo
Mar 6, 2013·Canadian Journal of Physiology and Pharmacology·Kawshik K ChowdhuryW Wayne Lautt
Jul 6, 2013·Canadian Journal of Physiology and Pharmacology·Kawshik K ChowdhuryW Wayne Lautt
Jan 1, 2014·Journal of Clinical Medicine·W Wayne Lautt, Hui Helen Wang
Feb 17, 2009·Metabolism: Clinical and Experimental·Barna PeitlZoltán Szilvássy
Jan 17, 2007·Metabolism: Clinical and Experimental·R T RibeiroM Paula Macedo
Feb 24, 2006·British Journal of Pharmacology·Maria P Guarino, M Paula Macedo
Jan 9, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui Helen WangW Wayne Lautt
Aug 28, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Maria P GuarinoM Paula Macedo
Jun 14, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Wolfgang Langhans

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