Insulin Signaling and Glucose Uptake in the Soleus Muscle of 30-Month-Old Rats After Calorie Restriction With or Without Acute Exercise

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Haiyan WangGregory D Cartee

Abstract

Exercise and calorie restriction (CR) can each improve insulin sensitivity in older individuals, but benefits of combining these treatments on skeletal muscle insulin signaling and glucose uptake are poorly understood, especially in predominantly slow-twitch muscles (eg, soleus). Accordingly, our purpose was to determine independent and combined effects of prior acute exercise and CR (beginning at 14 weeks old) on insulin signaling and glucose uptake in insulin-stimulated soleus muscles of 30-month-old rats. CR alone (but not exercise alone) versus ad libitum sedentary controls induced greater insulin-stimulated glucose uptake. There was a main effect of diet (CR > ad libitum) for insulin-stimulated Akt(Ser473) and Akt(Thr308) phosphorylation. CR alone versus ad libitum sedentary increased Akt substrate of 160kDa (AS160) Ser(588) phosphorylation and TBC1D1 Thr(596), but not AS160 Thr(642) phosphorylation or abundance of GLUT4, GLUT1, or hexokinase II proteins. Combined CR and exercise versus CR alone did not further increase insulin-stimulated glucose uptake although phosphorylation of Akt(Ser473), Akt(Thr308), TBC1D1(Thr596), and AMPK(Thr172) for the combined group exceeded values for CR and/or exercise alone. These results re...Continue Reading

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Citations

Oct 28, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Naveen SharmaGregory D Cartee
May 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Haiyan WangGregory D Cartee
Mar 22, 2018·International Journal of Molecular Sciences·Alberto ZulloFrancesco Paolo Mancini
Mar 9, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kentaro OkiGregory D Cartee
Jan 25, 2020·Journal of Cellular Physiology·Yu FengRengfei Shi
Oct 2, 2019·American Journal of Physiology. Endocrinology and Metabolism·Mark W PatakyGregory D Cartee
Nov 16, 2017·Physiological Research·G P MoraisA Sr da Silva
Feb 19, 2021·Frontiers in Physiology·Rafael L RovinaAdelino S R da Silva
Apr 4, 2021·International Journal of Molecular Sciences·Ana P PintoAdelino S R da Silva
Apr 11, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Manisha J OzaYogesh A Kulkarni

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