Insulin signaling meets mitochondria in metabolism.

Trends in Endocrinology and Metabolism : TEM
Zhiyong ChengMorris F White

Abstract

Insulin controls nutrient and metabolic homeostasis via the IRS-PI3K-AKT signaling cascade that targets FOXO1 and mTOR. Mitochondria, as the prime metabolic platform, malfunction during insulin resistance in metabolic diseases. However, the molecular link between insulin resistance and mitochondrial dysfunction remains undefined. Here we review recent studies on insulin action and the mechanistic association with mitochondrial metabolism. These studies suggest that insulin signaling underpins mitochondrial electron transport chain integrity and activity by suppressing FOXO1/HMOX1 and maintaining the NAD(+)/NADH ratio, the mediator of the SIRT1/PGC1α pathway for mitochondrial biogenesis and function. Mitochondria generate moderately reactive oxygen species (ROS) and enhance insulin sensitivity upon redox regulation of protein tyrosine phosphatase and insulin receptor. However, chronic exposure to high ROS levels could alter mitochondrial function and thereby cause insulin resistance.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S E ShoelsonM F White
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·C HuJ C Lawrence
Nov 1, 1995·Trends in Biochemical Sciences·Z Songyang, L C Cantley
Jun 27, 1997·The Journal of Biological Chemistry·D Sawka-VerhelleE Van Obberghen
Jul 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E SchmidW Dröge
Nov 13, 1998·The Journal of Biological Chemistry·D J BurksM F White
Mar 5, 1999·Science·D C Wallace
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·S Dhe-PaganonS E Shoelson
Aug 27, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E SchmidW Dröge
Oct 16, 1999·The Journal of Biological Chemistry·R E Rhoads
Oct 16, 1999·Brain Research. Molecular Brain Research·S Numan, D S Russell
Oct 5, 2001·Molecular and Cellular Biology·J N AndersenN P Møller
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·B H GoodpasterD E Kelley
Dec 14, 2001·Nature·P Maechler, C B Wollheim
Mar 28, 2002·The Journal of Biological Chemistry·Seung-Rock LeeSue Goo Rhee
Sep 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andrew R TeeJohn Blenis
Sep 28, 2002·Diabetes·David E KelleyVladimir B Ritov
Dec 19, 2002·Diabetologia·M BjörnholmJ R Zierath
May 17, 2003·Science·Kitt Falk PetersenGerald I Shulman
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Craig S StumpK Sreekumaran Nair
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mary Elizabeth PattiLawrence J Mandarino
Oct 3, 2003·The Journal of Biological Chemistry·Sun Sik BaeMorris J Birnbaum
Oct 9, 2003·The EMBO Journal·Nick R LeslieC Peter Downes
Dec 6, 2003·Science·Morris F White
Feb 13, 2004·The New England Journal of Medicine·Kitt Falk PetersenGerald I Shulman
Feb 26, 2004·Cell·Maria Carla MottaLeonard Guarente
Mar 30, 2004·Nature Cell Biology·Tomohiro IdeNobuhiro Yamada
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·James P McClungXin Gen Lei
Dec 24, 2004·Nature·Marc Montminy, Seung-Hoi Koo

❮ Previous
Next ❯

Citations

Jul 17, 2012·Antioxidants & Redox Signaling·Fei YinEnrique Cadenas
Jan 19, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Karin LeanderJohan Högberg
Sep 13, 2014·Oxidative Medicine and Cellular Longevity·María MuriachJorge M Barcia
Dec 21, 2010·Diabetology & Metabolic Syndrome·Nicolas Wiernsperger, Jeanrobert Rapin
May 11, 2011·The Journal of Clinical Investigation·Alison SleighDavid B Savage
Aug 19, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Bettina Mittendorfer
Sep 20, 2011·The Journal of Clinical Investigation·Marianna SadagurskiMorris F White
Feb 14, 2012·The Journal of Clinical Investigation·Pavan K BattiproluJoseph A Hill
Feb 15, 2012·Advances in Nutrition·Nishan S KalupahanaNaima Moustaid-Moussa
Mar 15, 2013·The Journal of Clinical Investigation·Fernanda G De Felice
Feb 22, 2012·Biological Trace Element Research·M BasakiH A Shamsaei
Dec 8, 2011·Antioxidants & Redox Signaling·Diane E Handy, Joseph Loscalzo
Mar 20, 2012·Journal of Medicinal Food·Soyoung KimTaesun Park
Mar 8, 2012·Nature Medicine·Zhiyong Cheng, Morris F White
Feb 26, 2013·Antioxidants & Redox Signaling·Zhiyong Cheng, Michael Ristow
Apr 23, 2011·Expert Opinion on Drug Metabolism & Toxicology·David E Amacher
Feb 9, 2016·Biochimie·Debasis MondalPartha K Chandra
Jul 24, 2015·Molecular Nutrition & Food Research·Jon MerlinDana S Hutchinson
Jun 8, 2015·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Alba BerlangaTeresa Auguet
Jan 28, 2016·Aging and Disease·Xiaoting LuoLiang-Jun Yan
Feb 9, 2013·Endocrinology and Metabolism Clinics of North America·Marianna Sadagurski, Morris F White
Jul 24, 2012·Trends in Endocrinology and Metabolism : TEM·Liana Roberts Stein, Shin-ichiro Imai
Jul 27, 2012·Trends in Endocrinology and Metabolism : TEM·Andrew M JamesMichael P Murphy
Jan 17, 2012·Trends in Endocrinology and Metabolism : TEM·Bhumsoo Kim, Eva L Feldman
Nov 2, 2011·Molecular Aspects of Medicine·Nishan S KalupahanaKate J Claycombe
Jul 6, 2011·General and Comparative Endocrinology·Michael A Caruso, Mark A Sheridan
Sep 15, 2010·The International Journal of Biochemistry & Cell Biology·Beverley A Murrow, Kyle L Hoehn
Dec 22, 2015·Molecular and Cellular Endocrinology·Rita T Brookheart, Jennifer G Duncan
Sep 20, 2015·Biochimica Et Biophysica Acta·Beatriz SantamariaÁngela M Valverde
Feb 18, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Fernanda G De FeliceSergio T Ferreira
Apr 9, 2013·Biochimica Et Biophysica Acta·Yanlan ZhouJichun Yang
Feb 11, 2011·Diabetes/metabolism Research and Reviews·Nicole StiegerMario Schiffer
Sep 20, 2011·Journal of Cellular Physiology·Sébastien MichelPatricia Renard

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.