Insulin signaling promotes germline proliferation in C. elegans.

Development
David MichaelsonE Jane Albert Hubbard

Abstract

Cell proliferation must be coordinated with cell fate specification during development, yet interactions among pathways that control these two critical aspects of development are not well understood. The coordination of cell fate specification and proliferation is particularly crucial during early germline development, when it impacts the establishment of stem/progenitor cell populations and ultimately the production of gametes. In C. elegans, insulin/IGF-like receptor (IIR) signaling has been implicated in fertility, but the basis for the fertility defect had not been previously characterized. We found that IIR signaling is required for robust larval germline proliferation, separate from its well-characterized role in preventing dauer entry. IIR signaling stimulates the larval germline cell cycle. This activity is distinct from Notch signaling, occurs in a predominantly germline-autonomous manner, and responds to somatic activity of ins-3 and ins-33, genes that encode putative insulin-like ligands. IIR signaling in this role acts through the canonical PI3K pathway, inhibiting DAF-16/FOXO. However, signaling from these ligands does not inhibit daf-16 in neurons nor in the intestine, two tissues previously implicated in other II...Continue Reading

References

Mar 1, 1976·Developmental Biology·D HirshM Klass
May 1, 1974·Genetics·S Brenner
Dec 2, 1993·Nature·C KenyonR Tabtiang
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·E B GilJ A Lees
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Oct 29, 2000·Science·A A HillE L Brown
Feb 22, 2001·Developmental Biology·D Drummond-Barbosa, A C Spradling
Mar 8, 2002·Current Biology : CB·Mensur Dlakić
Oct 26, 2002·Science·Andrew DillinCynthia Kenyon
Sep 24, 2004·BMC Developmental Biology·Tao LiuGarth I Patterson
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Elena SanchoHans Clevers
Jun 2, 2005·Trends in Genetics : TIG·Pierre FichelsonMichel Gho
Jun 16, 2005·Annals of the New York Academy of Sciences·Ross A BathgateRoger J Summers
Aug 16, 2005·Science·Leesa LaFever, Daniela Drummond-Barbosa
Feb 17, 2006·Developmental Biology·John MaciejowskiE Jane Albert Hubbard
Apr 25, 2006·Current Biology : CB·Masamitsu FukuyamaJoel H Rothman

❮ Previous
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Citations

Jun 8, 2011·Cold Spring Harbor Perspectives in Biology·Judith Kimble
Mar 30, 2013·Genome Research·Ashlyn D RitterAlbertha J M Walhout
Dec 3, 2010·Genome Biology·Ronald E Ellis, Qing Wei
Oct 23, 2010·PLoS Biology·James J CollinsPhillip A Newmark
Mar 29, 2014·PLoS Genetics·Diana Andrea Fernandes de AbreuQueelim Ch'ng
Mar 31, 2011·PloS One·Marco GalloDonald L Riddle
Feb 24, 2012·PloS One·Sebastian J HonnenOlaf Bossinger
Oct 16, 2013·Zoological Science·Toshie MatsumotoMasahiko Awaji
Mar 15, 2013·Biology of Reproduction·Edward D TarnawaDiego H Castrillon
May 22, 2013·The Journal of Cell Biology·Tiffiney R HartmanAlana M O'Reilly
Nov 19, 2015·Developmental Biology·Debasmita RoyE Jane Albert Hubbard
Sep 8, 2010·Current Opinion in Cell Biology·Hebao Yuan, Yukiko M Yamashita
Aug 2, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Slavica BerberHannah R Nicholas
Feb 22, 2011·Molecular Reproduction and Development·Katherine A Waters, Valerie Reinke
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Elizabeth T AblesDaniela Drummond-Barbosa
Mar 13, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Dorota Z Korta, E Jane Albert Hubbard
Nov 26, 2010·Genesis : the Journal of Genetics and Development·Shijing Luo, Coleen T Murphy
Nov 19, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andrew Moore
Jun 12, 2012·Biochemical and Biophysical Research Communications·Yohei MatsunagaTsuyoshi Kawano
Oct 16, 2012·Experimental Gerontology·Adam Antebi
Feb 25, 2014·Communicative & Integrative Biology·Xicotencatl Gracida, Christian R Eckmann
Apr 19, 2012·Cell Cycle·David V Tobin, Richard Mako Saito
Sep 26, 2014·Worm·Julia L Moore VogelZhirong Bao
Apr 10, 2012·Current Biology : CB·Diana DalfóE Jane Albert Hubbard
Mar 19, 2013·Current Biology : CB·Xicotencatl Gracida, Christian R Eckmann
Jan 24, 2012·Developmental Cell·Cristina Pallares-CartesAurelio A Teleman
Jun 19, 2012·Cell Stem Cell·Ruth Lehmann
Aug 17, 2014·Developmental Biology·Yutao Chen, L Ryan Baugh

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