Insulin, sodium-lithium countertransport, and microalbuminuria in hypertensive patients

Hypertension
G AndronicoG Cerasola

Abstract

Both microalbuminuria (>0.290 nmol/min [20 microg/min]) and high sodium-lithium countertransport (SLC) in diabetic or hypertensive humans are predictive of overt nephropathy and more aggressive cardiovascular complications, perhaps induced by insulin resistance. To analyze the relationships between microalbuminuria, SLC, microalbuminuria, and insulin in essential hypertension, we studied 90 hypertensive white patients, 25 of whom had microalbuminuria and 32 of whom were healthy. When urine sampling was completed for albuminuria determination, SLC was measured; all patients then underwent standard (75 g) oral glucose load to measure basal (0 minutes) and 2-hour glucose and insulin serum levels. Glucose-insulin ratio was used as insulin sensitivity index (ISI). In both hypertensive patients with normal microalbuminuria and those with pathological microalbuminuria, plasma insulin at 120 minutes was significantly higher than in control subjects. When the patients with pathological microalbuminuria were divided into thirds on the basis of their microalbuminuria, in the lower third, we found statistically significant less fasting insulin and higher basal ISI. SLC was higher in hypertensives than normotensives and, among hypertensives...Continue Reading

References

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Citations

Sep 8, 2000·Journal of Cardiovascular Pharmacology·F S Zollmann, M Paul
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·L Rothermund, M Paul
May 25, 2005·Journal of Internal Medicine·G MulèG Cerasola
Mar 9, 2006·The Journal of Clinical Hypertension·Giuseppe Mulè, Giovanni Cerasola
Feb 19, 2002·Journal of Human Hypertension·R PedrinelliM Mariani
Jun 19, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G AndronicoG Cerasola
Mar 4, 2000·American Journal of Hypertension·S CottoneG Cerasola

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