PMID: 9556350Jan 1, 1997Paper

Insulin therapy of prediabetes suppresses TH1 associated gene expression in BB rat pancreas

Autoimmunity
H KolbF W Scott

Abstract

Subcutaneous insulin treatment of young diabetes prone BB rats has been shown previously to suppress the development of autoimmune diabetes. In this study the hypothesis was tested that exogenous insulin may deviate the autoimmune process by acting on the Th1/Th2 cytokine balance in the pancreas. BB rats were implanted with pellets which continuously released insulin, at 50 d of age. Three weeks later cytokine mRNA expression in the pancreas and insulitis score were determined. While in control BB rats high levels of IFNgamma mRNA were detectable by RT-PCR, insulin treatment almost completely suppressed IFNgamma mRNA levels without concomitant upregulation of counterregulatory IL-10 and TGFbeta gene expression. Insulin also suppressed gene expression of inducible nitric oxide synthase. Mean insulitis scores were decreased after insulin treatment. We conclude that the protective effects of insulin treatment may not be due to the induction of protective Th2 immune reactivity but to general downregulation of immune activation in the pancreas, and hence also of Th1 autoimmunity.

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Citations

May 7, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E StrandellK Bendtzen
Jun 30, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V Bonnevie-NielsenT Dyrberg
Oct 7, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Cara L CartyGail P Jarvik
Oct 27, 2004·Immunology·Lynn M WilliamsBrian M J Foxwell
Sep 9, 2006·Journal of Cellular Biochemistry·Marcella PedullàGianpaolo Papaccio
May 14, 1999·The Journal of Clinical Endocrinology and Metabolism·W Y AlmawiS T Azar
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lynn WilliamsBrian Foxwell
Dec 25, 2004·Diabetes/metabolism Research and Reviews·Nora KlötingIngrid Klöting

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