Insulin transport into the brain

American Journal of Physiology. Cell Physiology
Sarah M Gray, Eugene J Barrett

Abstract

While there is a growing consensus that insulin has diverse and important regulatory actions on the brain, seemingly important aspects of brain insulin physiology are poorly understood. Examples include: what is the insulin concentration within brain interstitial fluid under normal physiologic conditions; whether insulin is made in the brain and acts locally; does insulin from the circulation cross the blood-brain barrier or the blood-CSF barrier in a fashion that facilitates its signaling in brain; is insulin degraded within the brain; do privileged areas with a "leaky" blood-brain barrier serve as signaling nodes for transmitting peripheral insulin signaling; does insulin action in the brain include regulation of amyloid peptides; whether insulin resistance is a cause or consequence of processes involved in cognitive decline. Heretofore, nearly all of the studies examining brain insulin physiology have employed techniques and methodologies that do not appreciate the complex fluid compartmentation and flow throughout the brain. This review attempts to provide a status report on historical and recent work that begins to address some of these issues. It is undertaken in an effort to suggest a framework for studies going forward....Continue Reading

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Citations

Nov 14, 2018·American Journal of Physiology. Endocrinology and Metabolism·Joshua A KulasColin K Combs
Mar 17, 2019·International Journal of Molecular Sciences·Hiraku Ono
Sep 13, 2019·International Journal of Molecular Sciences·Gabriele Antonio ZingaleGiuseppe Grasso
May 28, 2019·Frontiers in Physiology·Martin H LundqvistJan W Eriksson
Oct 31, 2020·Endocrine Reviews·William B Horton, Eugene J Barrett
Mar 4, 2021·Journal of Neuroendocrinology·Caitlin S Mitchell, Denovan P Begg
Mar 6, 2021·Frontiers in Nutrition·Josep Bassaganya-RieraMauro Serafini
Mar 13, 2021·Journal of Neuroendocrinology·Sharon R Ladyman, Virginia L Brooks
Apr 13, 2021·Molecular Metabolism·Joshua L Milstein, Heather A Ferris

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Methods Mentioned

BETA
imaging techniques
PCR

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