Insulin treatment increases brain nitric oxide and oxidative stress, but does not affect memory function in mice

Physiology & Behavior
I U YarubeIsmail Umar

Abstract

Insulin increases brain nitric oxide (NO) level but the mechanism and the significance of the effect on memory are not fully understood. This study aimed to demonstrate the mechanism of insulin-induced increase in oxidative stress (OS) and its consequences on learning and memory. Twenty four mice were assigned to groups (n = 6) and treated daily for seven days with water (control), insulin, insulin+Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) and L-NAME, respectively. Memory was assessed using Y-maze; NO, malondialdehyde (MDA) and glutathione peroxidase (GPx) in brain homogenate were also determined. There was no difference between the groups in the number of entries into the arms and time spent in them, and in number of and percentage alternations performed by the mice, indicating normal memory function of the control and treated mice. NO level in the insulin group was higher compared to the control (p = .018), while those of the other groups were statistically the same compared to the control group. MDA values in the insulin group were higher (p = .001) than those of the control, while those of the other groups were statistically the same compared to those of the control group. GPx activity in the insulin group was...Continue Reading

References

Mar 1, 1994·The Biochemical Journal·R G Knowles, S Moncada
Dec 19, 2000·Free Radical Biology & Medicine·F S FacchiniR A Stoohs
Oct 13, 2001·Neuroendocrinology·W KernH L Fehm
Jan 5, 2002·Cellular and Molecular Neurobiology·K GerozissisM Orosco
Jun 25, 2003·Neurology·G S WatsonS Craft
Jul 18, 2003·Current Diabetes Reports·Michelle A VincentMichael J Quon
Feb 26, 2004·Lancet Neurology·Suzanne Craft, G Stennis Watson
Apr 20, 2004·European Journal of Pharmacology·William A Banks
Oct 13, 2004·Neurology·Jose A LuchsingerRichard Mayeux
Mar 22, 2005·Brain Research·Zhen-Guo LiAnders A F Sima
Nov 23, 2006·Behavioural Brain Research·M MoosaviS Zahedi Asl
Nov 11, 2008·Mini Reviews in Medicinal Chemistry·Sónia CorreiaPaula I Moreira
Jun 3, 2009·Archives of Physiology and Biochemistry·Zvi Laron
Feb 24, 2010·Neurobiology of Learning and Memory·Ewan C McNayRobert S Sherwin
Feb 11, 2011·Diabetes/metabolism Research and Reviews·Louis MonnierDavid R Owens
Sep 8, 2012·Molecular Neurobiology·Rasoul GhasemiAbolhassan Ahmadiani
Sep 19, 2012·Mediators of Inflammation·Jan VítečekLukáš Kubala
Jan 1, 2014·Progress in Molecular Biology and Translational Science·Jenna BloemerVishnu Suppiramaniam
Jun 17, 2014·Diabetes·André KleinriddersC Ronald Kahn
Nov 22, 2014·Diabetes·Sarah M GrayEugene J Barrett
Oct 24, 2015·Diabetes·Fernanda G De Felice, Christian Benedict
May 22, 2016·Diabetologia·Éva A Csajbók, Gábor Tamás
Sep 23, 2016·Molecular Metabolism·Seung-Hwan LeeYoung-Bum Kim
May 11, 2018·Frontiers in Neuroscience·Christian Benedict, Claudia A Grillo
Feb 26, 2019·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Isyaku U YarubeIsma'il A Umar

❮ Previous
Next ❯

Citations

May 1, 2020·Antioxidants & Redox Signaling·Jian YangChunyu Zeng
Oct 13, 2019·Current Medicinal Chemistry·Agnieszka JankowskaGrażyna Chłoń-Rzepa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pathophysiology : the Official Journal of the International Society for Pathophysiology
I U YarubeIsma'il A Umar
Nigerian Journal of Physiological Sciences : Official Publication of the Physiological Society of Nigeria
I U YarubeM Ia Saleh
International Journal of Molecular Sciences
Xiaozhong ShanQiongxia Chai
© 2021 Meta ULC. All rights reserved