Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children

Clinical Endocrinology
A BereketT A Wilson

Abstract

We have recently demonstrated multiple aberrations in the GH-IGF axis in the sera of children with untreated insulin-dependent diabetes mellitus (IDDM) which were restored after insulin replacement. However, the net result of these alterations in the IGF system on the concentrations of free/biologically available IGF-I in the serum have not been examined directly in diabetic children. In the present study, the effect of diabetes and subsequent insulin replacement on the circulating free IGF-I concentrations are assessed. Fasting venous serum samples were obtained longitudinally, before and at various times after the initiation of insulin treatment in untreated diabetic subjects. Ten prepubertal, aged (mean +/- SEM) 6.3 +/- 1.0 years, and six adolescent, aged 12.7 +/- 1.1 years, subjects with newly diagnosed and untreated IDDM, and age and pubertal status-matched control children and adolescents were recruited. The serum samples were collected before initiating insulin treatment and 12-24 h, 1 week, and 1 month thereafter in subjects with IDDM. Insulin doses ranged from 0.5 to 1.2 U/kg/day. Free IGF-I concentration was assayed by a recently developed two-site immunoradiometric assay. Total IGF-I was measured by radioimmunoassay ...Continue Reading

Citations

Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Jan 27, 2000·Cytokine & Growth Factor Reviews·B R LackeyD M Henricks
Mar 22, 2014·International Journal of Endocrinology·Cosimo GianniniFrancesco Chiarelli
Nov 6, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Björn F LindgrenKerstin Brismar
Mar 2, 2016·Journal of Cellular and Molecular Medicine·Chao SunYue Zhou
Oct 14, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Clifford J Rosen
Sep 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jan Frystyk
Aug 15, 2014·Acta Diabetologica·Andrea GiustinaG Mazziotti
Feb 7, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·B FeldmannB O Boehm
Mar 30, 2011·The International Journal of Lower Extremity Wounds·Robert BlakytnyEdward B Jude
Oct 30, 1998·Endocrine Reviews·S JainM E Geffner
Jun 27, 2000·Diabetes/metabolism Research and Reviews·O M Herlihy, P Perros
Jan 16, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Guimei LiKenneth McCormick
May 11, 2018·Journal of Diabetes Research·Simona I Chisalita, J Ludvigsson
Oct 3, 2019·International Journal of Environmental Research and Public Health·Elisa SantiSusanna Esposito
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·R A Frost, C H Lang

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