Insulin treatment of diabetic rats reduces cardiac function in a lipopolysaccharide-induced systemic inflammation model

The Journal of Surgical Research
Satoshi HagiwaraTakayuki Noguchi

Abstract

Diabetes is a common comorbidity in patients with various medical conditions. Tight glucose control is known to improve systemic inflammation; however, whether it is effective in diabetic patients is unknown. The purpose of this study was to examine how strict glucose control affects systemic inflammation in diabetic patients. Male Wistar rats. We determined the effect of insulin therapy on cardiac function in a rat model of systemic inflammation. We administered lipopolysaccharide intravenously, with or without insulin, to streptozotocin-induced diabetic rats. After induction of systemic inflammation, we determined serum cytokine (IL-6 and TNFα) and nitrate/nitrite levels and measured cardiac function. Cytokine levels and cardiac function were significantly reduced in diabetic rats compared to non-diabetic rats. Moreover, insulin treatment was associated with higher cytokine levels and decreased cardiac function. In systemic inflammatory conditions, diabetes increases various proinflammatory mediators and inhibits cardiac function; insulin treatment exacerbates these effects. Thus, strict glucose control may not be desirable in diabetic patients with systemic inflammatory conditions.

References

Oct 12, 2001·European Journal of Heart Failure·S AdamopoulosD T Kremastinos
Jan 17, 2002·The New England Journal of Medicine·G van den BergheR Bouillon
Jul 10, 2002·Circulation·YingJie ChenRobert J Bache
Sep 6, 2003·Circulation Research·P B MassionJ-L Balligand
Feb 24, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Maria A Brown, W Keith Jones
Jun 14, 2005·Pharmacology & Therapeutics·R SchulzJ-L Balligand
Dec 24, 2005·Shock·Daniel G Remick, Peter A Ward
Jun 22, 2006·Endocrine, Metabolic & Immune Disorders Drug Targets·E L V CostaG P P Schettino
Apr 25, 2007·Critical Care Medicine·Alain Rudiger, Mervyn Singer
Jul 31, 2008·Critical Care Medicine·Moritoki EgiMichael Bailey
Feb 21, 2009·Journal of the American College of Cardiology·Paresh DandonaPriya Mohanty
Mar 26, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Donald E G GriesdaleDaniel Talmor

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Citations

Sep 18, 2012·Pulmonary Pharmacology & Therapeutics·Man-Ling LiuZhi-Chao Li

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