PMID: 3046411Jul 1, 1988

Insulin treatment of the insulin-dependent diabetic patient undergoing minor surgery. Continuous intravenous infusion compared with subcutaneous administration

C L ChristiansenK Hermansen


In a prospective randomised study in 20 insulin-dependent diabetics who had minor surgery under general anaesthesia we compared the metabolic responses to intravenous glucose-insulin-potassium infusion with those who had conventional subcutaneous insulin administration. The former treatment resulted in lower blood glucose levels both during the infusion period (p less than 0.05) as well as the entire observation period (operative, first and second postoperative days; p less than 0.01). More blood glucose values were within the intended range of 5 to 10 mmol/litre in the glucose-insulin-potassium as compared to the conventional group (48% versus 24%; p less than 0.01). The levels of lactate, 3-hydroxybutyrate, glycerol, alanine, glucagon, insulin and growth hormone did not differ between the two groups. The infusion regimen resulted in better glycaemic control both peri-and postoperatively than the conventional subcutaneous insulin regimen in insulin-dependent diabetic patients who have minor surgery.


Jul 1, 1979·British Journal of Anaesthesia·K G Alberti, D J Thomas
Mar 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·C K Christensen, C E Mogensen
Jun 1, 1972·The American Journal of the Medical Sciences·J D BagdadeR J Bulger
Jan 1, 1970·British Journal of Anaesthesia·R S Clarke
Jul 1, 1984·Anaesthesia·G M Hall
Feb 1, 1981·British Journal of Anaesthesia·C Traynor, G M Hall
Oct 1, 1981·Diabetologia·E J Weringer, E R Arquilla
Feb 1, 1963·The American Journal of Medicine·J A GALLOWAY, C R SHUMAN
Jan 1, 1965·Acta Medica Scandinavica·J SCHLICHTKRULLM JERSILD


Sep 26, 2003·Current Opinion in Critical Care·U N Das
Sep 30, 2005·Anesthesia and Analgesia·Erinn RhodesJoseph Wolfsdorf
Sep 17, 2009·Pediatric Diabetes·Peter BettsRagnar Hanas
May 25, 2006·Journal of Veterinary Dentistry·Eric Van Nice
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Ana Maria BuchleitnerDidac Mauricio
Jan 25, 2003·Journal of Internal Medicine·M BonnierP-A Jansson
Jul 31, 2007·Pediatric Diabetes·Peter BettsISPAD
Oct 8, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory L BrysonCanadian Ambulatory Anesthesia Research Education group

Related Concepts

glucose-insulin-potassium cardioplegic solution
Blood Glucose
Diabetes, Autoimmune
Glucose, (beta-D)-Isomer
Intravenous Infusion Procedures
Subcutaneous Injections
Surgical Procedures, Minor

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