Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain.

TheScientificWorldJournal
Edoardo Parrella, Valter D Longo

Abstract

Mutations that reduce glucose or insulin/insulin-like growth factor-I (IGF-I) signaling increase longevity in organisms ranging from yeast to mammals. Over the past 10 years, several studies confirmed this conserved molecular strategy of longevity regulation, and many more have been added to the complex mosaic that links stress resistance and aging. In this review, we will analyze the similarities that have emerged over the last decade between longevity regulatory pathways in organisms ranging from yeast, nematodes, and fruit flies to mice. We will focus on the role of yeast signal transduction proteins Ras, Tor, Sch9, Sir2, their homologs in higher organisms, and their association to oxidative stress and protective systems. We will discuss how the "molecular strategy" responsible for life span extension in response to dietary and genetic manipulations appears to be remarkably conserved in various organisms and cells, including neuronal cells in different organisms. Taken together, these studies indicate that simple model systems will contribute to our comprehension of aging of the mammalian nervous system and will stimulate novel neurotherapeutic strategies in humans.

Citations

Jul 8, 2010·Biogerontology·Alexios-Fotios A Mentis, Evangelia Kararizou
Aug 14, 2013·Rejuvenation Research·Jaime Font de Mora, Antonio Díez Juan
Dec 1, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark A McCormickBrian K Kennedy
Nov 8, 2012·PloS One·Daniele CampaRoberto Barale
Oct 8, 2014·Nature Reviews. Nephrology·Jeroen P KoomanPeter Stenvinkel
Sep 4, 2012·Ageing Research Reviews·Arnold De LoofLiliane Schoofs
Mar 18, 2015·Progress in Biophysics and Molecular Biology·Krishnendu MukherjeeAndreas Vilcinskas
Mar 8, 2014·Cell Cycle·Alexey A MoskalevAlex Zhavoronkov
Oct 30, 2013·FEMS Yeast Research·Margaret B Wierman, Jeffrey S Smith
Jul 22, 2019·Genes·Giusi TaorminaMario G Mirisola
Dec 3, 2016·Aging·Daniele Lettieri-BarbatoKatia Aquilano
Feb 18, 2016·Npj Aging and Mechanisms of Disease·Xiyan Li, Michael P Snyder
Nov 7, 2012·IUBMB Life·Emanuel CandeiasPaula I Moreira
Nov 9, 2018·Frontiers in Endocrinology·Masaaki Yamamoto, Yutaka Takahashi
Aug 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Gil B CarvalhoWilliam W Ja
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Fahmida RashaKevin Pruitt
Apr 17, 2021·Acta Neuropathologica Communications·Zoe ArvanitakisSteven E Arnold

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