Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Sanjay MukhopadhyayCarol F Farver

Abstract

Recent evidence suggests a role for the nuclear marker INSM1 in the diagnosis of neuroendocrine lung neoplasms. The aim of this study was to determine the utility of INSM1 as a marker of neuroendocrine differentiation using a large series of whole-tissue sections of primary lung neoplasms. We stained 345 primary lung neoplasms with INSM1, including 292 whole-tissue sections. Most cases were also stained with synaptophysin, chromogranin, and CD56. The tumors included 64 small cell lung carcinomas, 24 large cell neuroendocrine carcinomas, 64 carcinoid tumors (48 typical, 16 atypical), 130 adenocarcinomas, and 33 squamous cell carcinomas. For small cell lung carcinoma, the sensitivity of INSM1 (98%) was similar to synaptophysin (100%) and CD56 (95%) but considerably higher than chromogranin (83%). For large cell neuroendocrine carcinoma, CD56 (92%) and synaptophysin (88%) were more sensitive than INSM1 (75%), while chromogranin was less sensitive (46%). All markers stained 100% of carcinoid tumors, except one atypical carcinoid tumor, which was negative for INSM1. The sensitivity of INSM1 for neuroendocrine lung neoplasms as a group (95%) was similar to synaptophysin (98%) and CD56 (97%), but higher than chromogranin (84%). The sp...Continue Reading

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Citations

Mar 29, 2020·Cellular Oncology (Dordrecht)·B MahalakshmiBharath Kumar Velmurugan
Oct 26, 2018·Journal of Translational Medicine·Lin WangTao Cai
Apr 30, 2020·Journal of Surgical Oncology·Kazuhiro MinamiYoshimasa Maniwa
Mar 24, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Harrison K TsaiMarina Vivero
May 11, 2020·Endocrine Pathology·Damodaran NarayananRicardo V Lloyd
Dec 12, 2020·Expert Review of Anticancer Therapy·Jasna MetovicGiuseppe Pelosi
May 23, 2019·Molecular Cancer Research : MCR·Chiachen ChenMichael S Lan
Jul 28, 2019·Journal of the American Society of Cytopathology : JASC·Kartik ViswanathanAlain C Borczuk
Jan 12, 2021·International Journal of Surgical Pathology·Elsa SeijnhaeveMieke R Van Bockstal
Jan 9, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tamás ZomboriBence Kővári
Feb 2, 2020·Surgical Pathology Clinics·Alain C Borczuk
Jan 16, 2021·Nature Reviews. Disease Primers·Charles M RudinJulien Sage
Feb 4, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Julia Y Tsang, Gary M Tse
Feb 26, 2021·American Journal of Clinical Pathology·Maroa DridiGeorgia Karpathiou
Mar 3, 2021·International Journal of Surgical Pathology·Jae Yeon SeokXuemo Fan
Sep 24, 2020·Cellular Signalling·Chiachen Chen, Michael S Lan
Oct 5, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marina K BaineNatasha Rekhtman
May 20, 2021·Endocrine Pathology·Jasna MetovicMauro Papotti
Dec 17, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ching-Heng TingPao-Shu Wu

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

RUO XT OptiView DAB IHC

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