Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide

Internal Medicine
Masanori ShimizuYoshimasa Aso

Abstract

A 63-year-old man was diagnosed with diabetes mellitus at 42 years of age. He subsequently exhibited poor blood glucose control for a prolonged period, and his renal failure worsened. He therefore underwent hemodialysis and abdominal magnetic resonance imaging, which revealed a mass in the pancreatic tail. The immunoreactive insulin and C-peptide immunoreactivity levels were significantly elevated, and the results of a fasting test led to a diagnosis of insulinoma. The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia. This is a rare case of renal failure in which the CGM findings showed improvements in the blood glucose level after diazoxide administration.

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Citations

Sep 21, 2015·Diabetes & Metabolism·J-C Maiza, C Wantz
Dec 5, 2017·Clinical Medicine Insights. Endocrinology and Diabetes·Luca FoppianiGiancarlo Antonucci
Jan 14, 2020·Molecular and Clinical Oncology·Constantinos NastosAndromachi Vryonidou
Mar 22, 2019·Case Reports in Endocrinology·Eduardo Lozano-MelendezFabio Solis-Jimenez
Jan 1, 2021·Journal of the Endocrine Society·Stephanie KimElizabeth J Murphy

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