Insulitis in human type 1 diabetes

Annals of the New York Academy of Sciences
T Hanafusa, Akihisa Imagawa

Abstract

Pancreatic tissues were analyzed immunohistologically in patients with autoimmune and fulminant type 1 diabetes (T1D) and control subjects. Both beta and alpha cells were decreased in fulminant T1D, but only beta cells were significantly decreased in autoimmune T1D. Insulitis was seen in both subtypes of T1D, but it remained longer in autoimmune than in fulminant T1D. Lymphocytic infiltration to the exocrine pancreatic tissue was observed only in fulminant T1D, whereas immunologically abnormal findings, such as increased expression of MHC class I molecule and Fas antigen in islet cells and Fas-ligand expression in infiltrating lymphocytes, were detected only in autoimmune T1D. From these findings, together with clinical features, it could be concluded that in autoimmune T1D, beta cells are assumed to be destroyed through a long-standing autoimmune process, whereas in fulminant T1D, beta cells seem to be destroyed very rapidly, probably by a destructive process triggered by viral infection.

References

Jul 29, 2003·Diabetes Care·Akihisa ImagawaHideichi Makino
Dec 21, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Toshiaki Hanafusa, Akihisa Imagawa

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Citations

May 25, 2010·Seminars in Immunopathology·Patrick A RoweMark A Atkinson
May 9, 2012·Anatomy Research International·Norio KanatsunaAke Lenmark
Jul 28, 2010·Experimental & Molecular Medicine·Mi-Young SongByung-Hyun Park
Jun 22, 2011·World Journal of Diabetes·Hidekatsu Yanai, Sumie Moriyama
Nov 20, 2015·Diabetes·Martha Campbell-ThompsonMark A Atkinson
Aug 21, 2010·Endocrinology and Metabolism Clinics of North America·Terri C ThayerClayton E Mathews
Aug 29, 2012·European Journal of Clinical Investigation·Yaíma L LightfootClayton E Mathews
Apr 14, 2016·Journal of Autoimmunity·Mario R Ehlers
Jan 14, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Rubén Varela-CalvinoOscar J Cordero
Apr 20, 2017·Journal of Molecular Endocrinology·J Jason CollierSusan J Burke
May 26, 2018·Endocrine Journal·Kentaro ShigaUNKNOWN Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)
Aug 15, 2012·Endocrine Reviews·Valentina Di GialleonardoAlberto Signore

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