PMID: 9421359Jan 8, 1998Paper

int-2 oncogene amplification and prognosis in node-negative breast carcinoma

International Journal of Cancer. Journal International Du Cancer
L FioravantiG Di Fronzo

Abstract

The role of int-2 oncogene amplification on the prognosis of breast cancer patients was investigated in 128 patients with node-negative primary breast cancers given first-line local-regional treatments until relapse and with a median follow-up of 65 months. Tumours had been previously characterised for oestrogen (ER) and progesterone receptor (PgR) status and proliferative activity (3H-thymidine labelling index). Amplification of the int-2 oncogene occurred in 18% of cases and was significantly related to the presence of hormone receptors and to menopausal status or age, but not to proliferative status. Patients with tumours exhibiting int-2 amplification had a lower probability of disease-free survival than patients with non-amplified tumours and frequently developed local-regional recurrence. Disease-free survival analysis, adjusted for the prognostic contribution provided by tumour size, steroid receptors and proliferative rate, indicated that the association between int-2 amplification and risk of relapse was maintained and remained constant even in the presence of the other co-variates. Interestingly, int-2 amplification was a further prognostic discriminant within subsets of patients with a putatively good (i.e., tumour s...Continue Reading

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Citations

Nov 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DienstmannJ Tabernero
May 13, 2009·Maturitas·P KenemansR H M Verheijen
Sep 8, 2004·Maturitas·P KenemansR H M Verheijen
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Mar 10, 2001·European Journal of Immunology·M Sioud, M H Hansen
Jun 24, 2010·Cancer Research·Nancy E Hynes, Julien H Dey
Mar 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DienstmannJ Tabernero

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