Intact Imaging of Human Heart Structure Using X-ray Phase-Contrast Tomography

Pediatric Cardiology
Yukihiro KanekoTakuro Tsukube

Abstract

Structural examination of human heart specimens at the microscopic level is a prerequisite for understanding congenital heart diseases. It is desirable not to destroy or alter the properties of such specimens because of their scarcity. However, many of the currently available imaging techniques either destroy the specimen through sectioning or alter the chemical and mechanical properties of the specimen through staining and contrast agent injection. As a result, subsequent studies may not be possible. X-ray phase-contrast tomography is an imaging modality for biological soft tissues that does not destroy or alter the properties of the specimen. The feasibility of X-ray phase-contrast tomography for the structural examination of heart specimens was tested using infantile and fetal heart specimens without congenital diseases. X-ray phase-contrast tomography was carried out at the SPring-8 synchrotron radiation facility using the Talbot grating interferometer at the bending magnet beamline BL20B2 to visualize the structure of five non-pretreated whole heart specimens obtained by autopsy. High-resolution, three-dimensional images were obtained for all specimens. The images clearly showed the myocardial structure, coronary vessels, ...Continue Reading

References

Apr 1, 1995·Medical Physics·A Momose, J Fukuda
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Jun 19, 2009·Journal of Synchrotron Radiation·Samuel Alan McDonaldMarco Stampanoni
Apr 1, 2011·World Journal for Pediatric & Congenital Heart Surgery·Hiromi Kurosawa, Noriyasu Kawada
Oct 25, 2014·Journal of Synchrotron Radiation·Masato HoshinoNaoto Yagi
Nov 18, 2014·Current Heart Failure Reports·R Brandon StaceyW Gregory Hundley

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Citations

Oct 26, 2018·Circulation. Cardiovascular Imaging·Patricia Garcia-CanadillaAndrew C Cook
Mar 25, 2020·Journal of Medical Imaging·Marius ReichardtTim Salditt
Jun 6, 2020·Biomedical Optics Express·Marius ReichardtTim Salditt
Apr 5, 2020·The Annals of Thoracic Surgery·Ryuma IwakiYoshihiro Oshima
Apr 4, 2021·International Journal of Molecular Sciences·Lisa LeyssensGreet Kerckhofs

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Methods Mentioned

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X-ray
imaging techniques

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