Intact implicit probabilistic sequence learning in obstructive sleep apnea

Journal of Sleep Research
Dezso NemethZoltan Mari

Abstract

Obstructive sleep apnea (OSA) belongs to the sleep-related breathing disorders and is associated with cognitive impairments in learning and memory functions. The impairments in attention-demanding cognitive functions such as working memory and executive functions are well established in OSA; however, it remains unknown if less attention-demanding implicit sequence learning is affected. In the present study, we examined implicit sequence learning in OSA to probe the functional integrity of this fundamental learning mechanism. We used listening span to measure complex working memory capacity and the alternating serial reaction time (ASRT) task, which enables us to measure general skill learning and sequence-specific learning separately. Twenty OSA patients and 20 healthy controls participated in this study. Our data show dissociation between working memory and implicit sequence learning in OSA. Surprisingly, OSA patients showed preserved general skill and sequence-specific learning in spite of the possible hypoxia and sleep restriction. In contrast, working memory performance measured by listening span task was impaired in the OSA group. This finding suggests selective susceptibility of more attention-demanding cognitive function...Continue Reading

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Citations

Jul 16, 2013·Journal of Clinical and Experimental Neuropsychology·Eszter CsábiDezso Nemeth
Jan 23, 2016·Frontiers in Human Neuroscience·Eszter CsábiDezso Nemeth
Jan 6, 2016·Journal of Neural Transmission·Krzysztof KrystaRadosław Stepańczak
Jul 11, 2012·Journal of Sleep Research·Derk-Jan Dijk
Sep 23, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Karolina Janacsek, Dezso Nemeth
May 16, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Anne-Cécile TroussièreStéphanie Bombois
Apr 2, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Karolina Janacsek, Dezso Nemeth
Dec 14, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Karolina Janacsek, Dezso Nemeth
Oct 21, 2014·PloS One·Eszter CsabiDezso Nemeth
Sep 12, 2014·Current Opinion in Psychiatry·Masashi Okuro, Shigeto Morimoto
Jul 24, 2021·Cerebral Cortex Communications·Teodóra VékonyDezso Nemeth
Aug 9, 2021·Consciousness and Cognition·Jie Wu, Qiufang Fu

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