PMID: 11330505May 2, 2001Paper

Intact insulin, insulin propeptides, and intima-media thickness in the femoral artery in 58-year-old clinical healthy men--the Atherosclerosis and Insulin Resistance Study

Angiology
L BokemarkAtherosclerosis and Insulin Resistance Study

Abstract

The aim of this study was to examine the association between intact insulin, insulin propeptides, and femoral artery intima-media thickness. The design was a cross-sectional study and the study group (n = 391) consisted of randomly recruited clinically healthy 58-year-old Swedish men. The intima-media thickness of the common femoral artery was measured with ultrasound. Fasting plasma insulin; intact insulin; proinsulin; 32,33 split-proinsulin; and C-peptide concentrations were assessed. The results showed that the common femoral artery intima-media thickness correlated significantly and univariately with waist-hip ratio, systolic blood pressure, serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, ApoB, low-density lipoprotein peak particle size, and cigarette years. Furthermore, of intact insulin and insulin propeptides, only intact insulin and C-peptide were univariately associated with common femoral artery intima-media thickness (r= 0.14, p < 0.01; r= 0.18, p < 0.01; respectively). In a multiple regression analysis, common femoral artery intima-media thickness was independently associated with systolic blood pressure (beta-coefficient = 0.004, p = 0.002), ApoB (b...Continue Reading

References

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Apr 11, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·L BokemarkB Fagerberg

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Citations

Mar 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·L BokemarkUNKNOWN Atherosclerosis and Insulin Resistance sstudy (AIR)
Jun 13, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·B HedbladL Janzon
Mar 25, 2011·Diabetes/metabolism Research and Reviews·Cosimo GianniniC J H Kelnar
Jul 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Johannes Hulthe, Björn Fagerberg

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