Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant.

Psychopharmacology
Hendrik Dietrich, François Jenck

Abstract

Orexins play a key role in the maintenance of alertness and are implicated in the modulation of diverse physiological processes, including cognitive function. Almorexant, a dual orexin receptor antagonist, transiently and reversibly blocks the action of orexin peptides at both OX(1) and OX(2) receptors and increases time spent in rapid eye movement (REM) and non-REM sleep. We explored the direct effects on learning and memory of single and repeated administration of almorexant in rats. Following administration of high doses of almorexant (300 mg/kg, p.o.), scopolamine (0.8 mg/kg, i.p.), combination almorexant-scopolamine, or vehicle alone, rats were trained on a Morris water maze spatial navigation task, or on a passive avoidance task. Rats treated with almorexant learned the spatial navigation task with similar efficacy as vehicle-treated animals. After 4 days, almorexant-but not vehicle-treated rats had established spatial memory; after 8 days, spatial memory had been established in both vehicle-and almorexant-treated rats. Scopolamine-treated rats failed to learn the spatial task. Both vehicle-and almorexant-but not scopolamine-treated rats demonstrated passive avoidance learning. Almorexant did not ameliorate scopolamine-in...Continue Reading

References

Mar 1, 1992·Pharmacology, Biochemistry, and Behavior·R K McNamara, R W Skelton
May 1, 1984·Journal of Neuroscience Methods·R Morris
Jul 30, 1982·Science·R T BartusA S Lippa
Jul 1, 1995·Behavioural Brain Research·C Smith
Jan 1, 1997·Annual Review of Psychology·B J Everitt, T W Robbins
Aug 12, 1999·Psychophysiology·W Plihal, J Born
Jul 25, 2000·Trends in Neurosciences·T S Kilduff, C Peyron
Nov 3, 2001·Science·P Maquet
Sep 10, 2002·Peptides·Laura B JaegerJohn E Morley
Oct 3, 2003·Neurobiology of Learning and Memory·Paul E Gold
Apr 2, 2005·Neuroscience·H R Smith, K C H Pang
Apr 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maan Gee LeeBarbara E Jones
Oct 28, 2005·Nature·Clifford B SaperJun Lu
Oct 28, 2005·Nature·Robert Stickgold
Nov 11, 2005·The FEBS Journal·Luis de Lecea, J Gregor Sutcliffe
Nov 22, 2005·Sleep·Robert Stickgold, Matthew P Walker
Dec 2, 2005·Annual Review of Psychology·Matthew P Walker, Robert Stickgold
Jun 14, 2006·Journal of Cognitive Neuroscience·Björn H RaschSteffen Gais
Sep 8, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jan BornSteffen Gais
Jan 30, 2007·Nature Medicine·Catherine Brisbare-RochFrançois Jenck
Apr 10, 2007·Neuroscience·E von Linstow RoloffG Riedel
Oct 4, 2007·Frontiers in Neuroendocrinology·Kousaku Ohno, Takeshi Sakurai
Oct 26, 2007·PLoS Biology·Virginie SterpenichPierre Maquet
Nov 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Steffen GaisPhilippe Peigneux
Feb 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Björn RaschJan Born

❮ Previous
Next ❯

Citations

May 18, 2012·Psychopharmacology·Michel A SteinerFrancois Jenck
Nov 13, 2013·Neuropeptides·Daniel Hoyer, Laura H Jacobson
Dec 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michel A SteinerFrançois Jenck
Aug 21, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregory S ParksThomas S Kilduff
May 14, 2011·Trends in Pharmacological Sciences·Takeshi Sakurai, Michihiro Mieda
Mar 8, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gennady N SmaginConnie Sánchez
Oct 10, 2013·British Journal of Pharmacology·Jingcheng LiLuis de Lecea
Jul 22, 2014·Medicinal Research Reviews·Quanhui ChenDong Gao
May 15, 2013·Current Opinion in Neurobiology·Takeshi Sakurai
Jun 9, 2016·Journal of Neurogenetics·Terrence McDonaldJohn J Renger
Jun 17, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·África FloresFernando Berrendero
May 14, 2011·Developmental Neurobiology·Jason Rihel, Alexander F Schier
Sep 5, 2013·Endocrinology·Dyan Sellayah, Devanjan Sikder
Nov 20, 2016·Annual Review of Pharmacology and Toxicology·Paul J ColemanJohn J Renger
Jul 20, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yoshitaka TanakaSatoru Hisada
Feb 12, 2020·Behavioural Brain Research·Sudabeh SalehabadiTaghi Lashkarbolouki

❮ Previous
Next ❯

Software Mentioned

GEMINI
Prism
HVS Image
Statistica
GraphPad

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.