Intact spatial learning in adult Tg2576 mice

Neurobiology of Aging
J L BizonMichelle M Nicolle

Abstract

Tg2576 mice, a transgenic model of amyloid pathology associated with Alzheimer's disease (AD), develop measurable levels of soluble amyloid beta1-40 and 1-42 by 6 months of age and amyloid plaque deposition in cortex, hippocampus and amygdala by 10 months of age. To investigate whether non-hippocampal learning strategies would predominate coincident with the age-related increase in Abeta load in the hippocampal region, we measured learning strategies in the T-maze and a redundant cued version of the water maze. Each of these tasks can be solved using either hippocampal or non-hippocampal learning strategies and has proved sensitive to hippocampal disruption in other settings. The results revealed subtle differences in T-maze and water maze performance in Tg2576 mice compared to controls. Surprisingly, however, Tg2576 mice were not impaired relative to non-transgenic littermates on any measures of hippocampal dependent behavior assessed in these tasks. These data suggest that the medial temporal lobe retains considerable function in 15-month-old Tg2576 mice despite significant Abeta pathology.

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Citations

Nov 27, 2007·Acta Neuropathologica·Charles DuyckaertsBenoît Delatour
Oct 31, 2006·Behavior Genetics·Jason L Eriksen, Christopher G Janus
Feb 8, 2008·Genes, Brain, and Behavior·C Le CudennecB Delatour
Nov 23, 2011·The Journal of Cell Biology·Lei WenWen-Cheng Xiong
Sep 15, 2010·Life Sciences·Sunita SharmaHolly Brown-Borg
Mar 21, 2009·Annales pharmaceutiques françaises·C DuyckaertsM-C Potier
Feb 11, 2014·Behavioural Brain Research·John A Kennard, Fiona E Harrison
Oct 22, 2011·Neurobiology of Aging·Susanna PietropaoloYoon H Cho
May 6, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Celeste Di PaoloMercedes Gómez
Sep 8, 2010·Neurobiology of Aging·Saioa LagadecYoon H Cho
Oct 22, 2013·Physiology & Behavior·Adam DerenneMorgan Frerking
Aug 5, 2020·Behavior Research Methods·Madeleine ClealMatthew O Parker
Jun 22, 2010·Mechanisms of Ageing and Development·Sunita SharmaHolly M Brown-Borg

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