Integral lipids of hair and stratum corneum

EXS
P W Wertz

Abstract

Within the past 10 years, covalently bound lipids have been identified both in wool and hair and in epidermal stratum corneum. In hair, fatty acids, the most abundant of which is 18-methyleicosanoic acid, are attached via thioester linkages to protein at the outer surface of cuticle cells. This lipid layer, the fatty layer or F-layer, is thought to be of major significance in determining the surface properties of hair and wool. In epidermal stratum corneum, the covalently attached lipid has been identified as an omega-hydroxyceramide consisting of 30-through 34-carbon omega-hydroxyacids amide-linked to sphingosine bases. The hydroxyceramide molecules are attached to the outer surface of the cornified envelope through ester linkages, and provide a monolayer covering the outer surface of all corneocytes. This covalently bound lipid layer, or lipid envelope, interacts with free lipids and has a major influence on the organization of lipid lamellar structures in the intercellular space.

Citations

Feb 15, 2020·Antibiotics·Carol L Fischer
May 20, 2014·Ukrainskiĭ biokhimicheskiĭ zhurnal·V M TkachukH M Sediloc
Jul 4, 1998·Biochimica Et Biophysica Acta·D KuempelP W Wertz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Investigative Dermatology
P W WertzD T Downing
Archives of Dermatology
P W WertzD T Downing
Journal of the American Academy of Dermatology
J T BortzD T Downing
© 2021 Meta ULC. All rights reserved