Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques

Science
D J HazudaJohn W Shiver

Abstract

We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained suppression of viremia, preserving CD4 levels and permitting the induction of virus-specific cellular immunity. L-870812 was also active in chronic infection; however, the magnitude and durability of the effect varied in conjunction with the pretreatment immune response and viral load. These studies demonstrate integrase inhibitor activity in vivo and suggest that cellular immunity facilitates chemotherapeutic efficacy in retroviral infections.

References

Oct 1, 1996·Genome Research·C A HeidP M Williams
Jun 29, 1999·Advances in Virus Research·D Esposito, R Craigie
Jun 29, 1999·Advances in Virus Research·E Asante-Appiah, A M Skalka
Mar 7, 2000·Current Medicinal Chemistry·F Lebon, M Ledecq
Mar 21, 2000·Medicinal Research Reviews·H JonckheereE De Clercq
Aug 9, 2002·The New England Journal of Medicine·Susan J LittleDouglas D Richman

❮ Previous
Next ❯

Citations

Dec 14, 2004·Applied Microbiology and Biotechnology·Julia MagdenTero Ahola
Dec 28, 2011·Medical Microbiology and Immunology·Thomas VollbrechtRika Draenert
Jan 20, 2006·Journal of Medicinal Chemistry·Vasu NairNouri Neamati
Feb 25, 2005·Nature Reviews. Drug Discovery·Yves PommierChristophe Marchand
Jan 5, 2005·Nature Reviews. Immunology·Francisco González-Scarano, Julio Martín-García
Jan 17, 2007·Nature Reviews. Microbiology·Yefei HanRobert F Siliciano
Jun 22, 2005·Chemical Communications : Chem Comm·Goverdhan Mehta, Subhrangsu Roy
Jul 25, 2008·The New England Journal of Medicine·Roy T SteigbigelUNKNOWN BENCHMRK Study Teams
Mar 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ahmad R SedaghatRobert F Siliciano
Nov 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gabriele B Beck-EngeserMatthias Wabl
Nov 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pamela Bean
Sep 10, 2011·AIDS Research and Human Retroviruses·Koen K A Van Rompay
May 26, 2007·Human Gene Therapy·Nicola J Philpott, Adrian J Thrasher
Aug 23, 2008·The Journal of Antimicrobial Chemotherapy·B RoquebertUNKNOWN French ANRS HIV-2 Cohort (ANRS CO 05 VIH-2)
Feb 18, 2009·The Journal of Antimicrobial Chemotherapy·Isabelle MaletAnne-Genevieve Marcelin
Aug 26, 2010·The Journal of Antimicrobial Chemotherapy·Axel FunMonique Nijhuis
Aug 29, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Edwin DeJesusUNKNOWN 183-0101 Study Team
Mar 20, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hiroyu HatanoSteven G Deeks
Aug 13, 2005·Proceedings. Biological Sciences·Alison P Galvani
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Eric J Arts, Daria J Hazuda
Jun 30, 2007·Science·Indrani SarkarFrank Buchholz
May 28, 2009·Antimicrobial Agents and Chemotherapy·Michel L NtemgwaMark A Wainberg
Dec 24, 2008·Antimicrobial Agents and Chemotherapy·Gregg S JonesManuel Tsiang
Jan 30, 2008·Antimicrobial Agents and Chemotherapy·Isabelle MaletAnne-Geneviève Marcelin
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Brandon AsonWilliam S Reznikoff
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Deborah J Lee, W Edward Robinson
Oct 22, 2008·Annual Review of Pharmacology and Toxicology·Daria HazudaLarissa Wenning
Mar 9, 2007·Retrovirology·Maurizio CianfrigliaLucia Palmisano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.