Integrase strand transfer inhibitor-based regimen is related with a limited HIV-1 V3 loop evolution in clinical practice

Virus Genes
Claudia AlteriM M Santoro

Abstract

Integrase-strand-transfer inhibitors (INSTIs) are known to rapidly reduce HIV-1 plasma viral load, replication cycles, and new viral integrations, thus potentially limiting viral evolution. Here, we assessed the role of INSTIs on HIV-1 V3 evolution in a cohort of 89 HIV-1-infected individuals starting an INSTI- (N = 41, [dolutegravir: N = 1; elvitegravir: N = 3; raltegravir: N = 37]) or a non-INSTI-based (N = 48) combined antiretroviral therapy (cART), with two plasma RNA V3 genotypic tests available (one before [baseline] and one during cART). V3 sequences were analysed for genetic distance (Tajima-Nei model) and positive selection (dN/dS ratio). Individuals were mainly infected by B subtype (71.9%). Median (interquartile-range, IQR) plasma viral load and CD4 + T cell count at baseline were 4.8 (3.5-5.5) log10 copies/mL and 207 (67-441) cells/mm3, respectively. Genetic distance (median, IQR) between the V3 sequences obtained during cART and those obtained at baseline was 0.04 (0.01-0.07). By considering treatment, genetic distance was significantly lower in INSTI-treated than in non-INSTI-treated individuals (median [IQR]: 0.03[0.01-0.04] vs. 0.05[0.02-0.08], p = 0.026). In line with this, a positive selection (defined as dN/d...Continue Reading

References

May 20, 1999·Molecular Membrane Biology·T L Hoffman, R W Doms
Mar 15, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pierre DelobelJacques Izopet
Jun 7, 2005·Trends in Microbiology·Roland R Regoes, Sebastian Bonhoeffer
Nov 15, 2005·Science·Chih-chin HuangPeter D Kwong
Apr 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura WatersGraeme Moyle
Feb 18, 2009·The Journal of Antimicrobial Chemotherapy·Isabelle MaletAnne-Genevieve Marcelin
Dec 1, 2010·Antimicrobial Agents and Chemotherapy·Masanori KobayashiTamio Fujiwara
Mar 25, 2011·The Lancet Infectious Diseases·L P R VandekerckhoveUNKNOWN European Consensus Group on clinical management of tropism testing
Feb 6, 2013·Theranostics·Elisa VicenziGuido Poli
Nov 8, 2013·The New England Journal of Medicine·Sharon L WalmsleyUNKNOWN SINGLE Investigators
May 21, 2014·The Journal of Antimicrobial Chemotherapy·Stéphanie RaymondJacques Izopet
Apr 8, 2015·AIDS·Thibault MesplèdeMark A Wainberg
Aug 22, 2015·Expert Review of Anti-infective Therapy·Tae Eun ParkRoopali Sharma
Nov 20, 2016·Medicine·Antonella CastagnaUNKNOWN ICONA Foundation Study Group
Sep 29, 2017·Expert Opinion on Investigational Drugs·Yingshan HanMark A Wainberg
Dec 16, 2017·The Journal of Antimicrobial Chemotherapy·Pierre GantnerSamira Fafi-Kremer

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Software Mentioned

Mega6
SNAP
SPSS
R
OSCAR
INSTIs

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