Integrated Analysis and Visualization of Group Differences in Structural and Functional Brain Connectivity: Applications in Typical Ageing and Schizophrenia

PloS One
Carolyn D LangenWiro J Niessen

Abstract

Structural and functional brain connectivity are increasingly used to identify and analyze group differences in studies of brain disease. This study presents methods to analyze uni- and bi-modal brain connectivity and evaluate their ability to identify differences. Novel visualizations of significantly different connections comparing multiple metrics are presented. On the global level, "bi-modal comparison plots" show the distribution of uni- and bi-modal group differences and the relationship between structure and function. Differences between brain lobes are visualized using "worm plots". Group differences in connections are examined with an existing visualization, the "connectogram". These visualizations were evaluated in two proof-of-concept studies: (1) middle-aged versus elderly subjects; and (2) patients with schizophrenia versus controls. Each included two measures derived from diffusion weighted images and two from functional magnetic resonance images. The structural measures were minimum cost path between two anatomical regions according to the "Statistical Analysis of Minimum cost path based Structural Connectivity" method and the average fractional anisotropy along the fiber. The functional measures were Pearson's c...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sophie AchardEd Bullmore
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Apr 28, 2006·Current Opinion in Psychiatry·Marek KubickiMartha E Shenton
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·J S DamoiseauxC F Beckmann
Jan 24, 2007·Neurobiology of Aging·M Arfan IkramMonique M B Breteler
Sep 27, 2007·American Journal of Public Health·A B Hollingshead, F C Redlich
Feb 27, 2008·International Journal of Biomedical Imaging·S JbabdiH Benali
Jul 9, 2008·Memory & Cognition·Gregoire Borst, Stephen M Kosslyn
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·C J HoneyP Hagmann
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Apr 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Nicola FilippiniClare E Mackay
May 13, 2009·Genetic Epidemiology·Xiaoyi GaoMichael A Province
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithChristian F Beckmann
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Oct 16, 2009·Human Brain Mapping·Martijn P van den Heuvel, Hilleke E Hulshoff Pol
Dec 29, 2009·NeuroImage·Andrew ZaleskyEdward T Bullmore
Jan 26, 2010·Journal of Neuroscience Methods·Patric HagmannOlaf Sporns
Feb 2, 2010·NeuroImage·Christopher J HoneyOlaf Sporns
Jun 29, 2010·Nature Genetics·Greg Gibson
Jul 27, 2010·NeuroImage·Anjali KrishnanHervé Abdi
Dec 15, 2010·NeuroImage·Renske de BoerWiro J Niessen
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Oct 18, 2011·Journal of Neuroscience Methods·Leila CammounPatric Hagmann
Oct 18, 2011·European Journal of Epidemiology·M Arfan IkramMeike W Vernooij
Jan 18, 2012·NeuroImage·Bruce Fischl
Jan 18, 2012·NeuroImage·Stephen M Smith
Feb 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithKamil Ugurbil
Mar 1, 2012·NeuroImage·Christian F Beckmann
Mar 6, 2012·NeuroImage·Alex FornitoEdward T Bullmore
May 23, 2012·PloS One·John Darrell Van HornArthur W Toga
Sep 19, 2012·Schizophrenia Bulletin·Tonya WhiteVincent A Magnotta
Dec 6, 2012·The American Journal of Psychiatry·Ricardo E JorgeVincent A Magnotta

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

ANFI
FreeSurfer
DTIFit
Connectograms
FSL
SAMSCo
AFNI

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