Integrated Analysis of Distant Metastasis-Associated Genes and Potential Drugs in Colon Adenocarcinoma

Frontiers in Oncology
Miaowei WuXiao-Fang Yu

Abstract

Background: Most colon adenocarcinoma (COAD) patients die of distant metastasis, though there are some therapies for metastatic COAD. However, the genes exclusively expressed in metastatic COAD remain unclear. This study aims to identify prognosis-related genes associated with distant metastasis and develop therapeutic strategies for COAD patients. Methods: Transcriptomic data from The Cancer Genome Atlas (TCGA; n = 514) cohort were analyzed as a discovery dataset. Next, the data from the GEPIA database and PROGgeneV2 database were used to validate our analysis. Key genes were identified based on the differential miRNA and mRNA expression with respect to M stage. The potential drugs targeting candidate differentially expressed genes (DEGs) were also investigated. Results: A total of 127 significantly DEGs in patients with distant metastasis compared with patients without distant metastasis were identified. Then, four prognosis-related genes (LEP, DLX2, CLSTN2, and REG3A) were selected based on clustering analysis and survival analysis. Finally, three compounds targeting the candidate DEGs, including ajmaline, TTNPB, and dydrogesterone, were predicted to be potential drugs for COAD. Conclusions: This study revealed that distant ...Continue Reading

References

Nov 4, 2010·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Nov 5, 2011·Frontiers in Pharmacology·Harry A FozzardDorothy A Hanck
Jun 20, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farhad AzimiJohn F Thompson
Sep 21, 2012·Channels·William J Brackenbury
Mar 22, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Heath A Smith, Yibin Kang
Sep 24, 2013·Japanese Journal of Clinical Oncology·Daisuke AkashiHidenori Kato
Dec 17, 2014·Molecular Cancer·Virginie DriffortSébastien Roger
Dec 19, 2014·BMC Cancer·Chirayu Pankaj Goswami, Harikrishna Nakshatri
Jan 24, 2015·Nature Reviews. Immunology·Takanori KitamuraJeffrey W Pollard
Jan 28, 2015·Molecular Cancer·Michaela NelsonWilliam J Brackenbury
May 16, 2015·Nucleic Acids Research·Ioannis S VlachosArtemis G Hatzigeorgiou
Aug 19, 2015·Frontiers in Pharmacology·Sébastien RogerPierre Besson
Feb 24, 2016·Frontiers in Pharmacology·Mohamed Chahine, Jean-François Desaphy
Sep 22, 2016·Nucleic Acids Research·Allan Peter DavisCarolyn J Mattingly
Nov 5, 2016·Methods in Molecular Biology·Monica Munoz-Torres, Seth Carbon
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Apr 25, 2017·OncoTargets and Therapy·Zhou-Feng ChenRui-Fang Jin
Dec 2, 2017·Nucleic Acids Research·Tomas TokarIgor Jurisica
Mar 3, 2018·Surgical Oncology Clinics of North America·Kabir Mody, Tanios Bekaii-Saab
May 15, 2018·Journal of Gastrointestinal Oncology·Nesrine MejriHamouda Boussen
Jul 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hatice Gumushan Aktas, Tuba Akgun
Oct 26, 2018·Circulation·Ming LeiChristopher L-H Huang
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 17, 2019·Cellular Oncology (Dordrecht)·Ahmad GhasemiSeyed Isaac Hashemy
Apr 5, 2019·Nature Communications·Yingyao ZhouSumit K Chanda
Aug 8, 2019·International Journal of Molecular Sciences·Pankaj AhluwaliaRavindra Kolhe
Oct 22, 2019·Lancet·Evelien DekkerMichael B Wallace
Nov 2, 2019·Endocrine Connections·Juan Carlos Juárez-CruzNapoleón Navarro-Tito

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-Seq
miRNA-Seq
biopsies

Software Mentioned

DIANA
Metascape
ONCOMINE
miRPath
Search Tool for the Retrieval
edgeR
CMap
Cytoscape
survminer
pheatmap

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.