Integrated analysis of gene expression, alteration and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer.

3 Biotech
Chun-Yue WengYa-Jun Wang

Abstract

Even though cell-cell adhesion molecule carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is extensively studied since the discovery, the role of CEACAM1 in different cancers is not completely clarified. In the present study, we examined CEACAM1 expression and its association with patient survival in various cancers by analysis of multiple databases. Oncomine database analysis revealed that CEACAM1 expression was upregulated in lung and pancreatic cancers, but downregulated in colorectal and head and neck cancers. PrognoScan and Kaplan‑Meier analyses showed that colorectal cancer patients as well as head and neck cancer patients with high CEACAM1 expression exhibited a higher overall survival rate. STRING analysis identified CEACAM3, CEACAM8, FN1, etc. as CEACAM1 interactors. Gene alteration analysis showed that CEACAM1 mutation predominantly occurred in the N-terminal. Coexpression analysis demonstrated that CEACAM1 had distinct coexpressed genes in different cancers, but KRT protein was consistently coexpressed with CEACAM1 in diverse cancer types. All the observations supported that CEACAM1 can serve as a diagnostic marker for some cancers, such as pancreatic cancer. And high CEACAM1 expression provides a b...Continue Reading

References

May 23, 1997·Science·L ZhangK W Kinzler
Aug 15, 2001·Experimental Cell Research·N BeaucheminW Zimmermann
Apr 8, 2004·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Mar 16, 2007·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Apr 21, 2007·Pancreas·Diane M SimeoneCraig D Logsdon
Apr 28, 2009·BMC Medical Genomics·Hideaki MizunoAkinori Sarai
Jan 1, 2004·Handbook of Experimental Pharmacology·A K Horst, C Wagener
Mar 18, 2011·International Journal of Cancer. Journal International Du Cancer·Junji IedaHiroki Yamaue
Jul 29, 2011·Nature·Ryan D MorinMarco A Marra
Aug 17, 2012·Nature·Somasekar SeshagiriFrederic J de Sauvage
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
May 21, 2013·Nature Genetics·Allen S HoTimothy A Chan
Aug 2, 2013·Cancer Metastasis Reviews·Nicole Beauchemin, Azadeh Arabzadeh
Nov 5, 2014·Nature·Yu-Hwa HuangRichard S Blumberg
Apr 10, 2015·Nature Communications·Agnieszka K WitkiewiczErik S Knudsen
Jun 16, 2016·The Journal of Biological Chemistry·Chunyue WengJohn E Shively
Oct 21, 2016·Cell Reports·Marios GiannakisLevi A Garraway
Dec 28, 2016·PLoS Medicine·Celine LefebvreFabrice André
Apr 27, 2017·The New England Journal of Medicine·Mariam Jamal-HanjaniUNKNOWN TRACERx Consortium
Aug 16, 2017·Oncoimmunology·Matthew DanknerNicole Beauchemin
Mar 30, 2018·Cell Systems·Kyle EllrottUNKNOWN Cancer Genome Atlas Research Network
Apr 7, 2018·Cancer Cell·Alison M TaylorMatthew Meyerson
Nov 9, 2018·Journal of Immunology Research·Andreea CalinescuIoana A Badarau
Jan 16, 2019·Nature Genetics·Vinayak BhandariRobert G Bristow

❮ Previous
Next ❯

Citations

Dec 1, 2020·Heliyon·Deepak SayeeramDivijendra Natha Reddy S

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Björn Obrink
Cancer Immunology, Immunotherapy : CII
Gal MarkelJacob Schachter
Acta Biochimica Et Biophysica Sinica
Changcheng YangFeng Gao
© 2021 Meta ULC. All rights reserved