Integrated analysis of halogenated organic pollutants in sub-millilitre volumes of venous and umbilical cord blood sera

Analytical and Bioanalytical Chemistry
Joan O GrimaltEsther Vizcaino

Abstract

A rapid, robust and economical method for the analysis of persistent halogenated organic compounds in small volumes of human serum and umbilical cord blood is described. The pollutants studied cover a broad range of molecules of contemporary epidemiological and legislative concern, including polychlorobiphenyls (PCBs), polychlorobenzenes (CBs), hexachlorocyclohexanes (HCHs), DDTs, polychlorostyrenes (PCSs) and polybromodiphenyl ethers (PBDEs). Extraction and clean-up with n-hexane and concentrated sulphuric acid was followed with analysis by gas chromatography coupled to electron capture (GC-ECD) and GC coupled to negative ion chemical ionisation mass spectrometry (GC-NICI-MS). The advantages of this method rest in the broad range of analytes and its simplicity and robustness, while the use of concentrated sulphuric acid extraction/clean-up destroys viruses that may be present in the samples. Small volumes of reference serum between 50 and 1000 microL were extracted and the limits of detection/quantification and repeatability were determined. Recoveries of spiked compounds for the extraction of small volumes (> or = 300 microL) of the spiked reference serum were between 90% and 120%. The coefficients of variation of repeatabili...Continue Reading

References

Nov 1, 1977·The Science of the Total Environment·G Lunde, A Bjorseth
Nov 14, 2001·Archives of Environmental Contamination and Toxicology·L HovanderE Klasson Wehler
Feb 5, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·B GómaraM J González
May 10, 2002·Environmental Science & Technology·Cathrine ThomsenGeorg Becher
Jul 26, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jean-François Focant, Edwin De Pauw
Apr 20, 2004·Environmental Pollution·K C Jones, P de Voogt
May 1, 2004·Environmental Science & Technology·Ingrid VivesDamià Barceló
Mar 30, 2006·Environmental Science & Technology·Daniel CarrizoMaties Torrent
Aug 22, 2007·Analytical and Bioanalytical Chemistry·Michele M SchantzStephen A Wise
Aug 23, 2007·Environmental Science & Technology·Daniel CarrizoMaties Torrent
Apr 1, 1984·Environmental Science & Technology·R Kaminsky, R A Hites

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Citations

Sep 20, 2011·Environmental Science and Pollution Research International·Maria N ManacaPedro L Alonso
Mar 5, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kai JiaChanghu Xue
Apr 7, 2011·Journal of Environmental Monitoring : JEM·Alan ShlosbergKurunthachalam Kannan
Apr 8, 2011·International Journal of Epidemiology·Mònica GuxensUNKNOWN INMA Project
May 3, 2014·Environmental Health Perspectives·Esther VizcainoAdonina Tardón
May 9, 2013·Environment International·Eva MoralesUNKNOWN INMA Project
Feb 4, 2014·Environment International·Esther VizcainoAdonina Tardon
Jan 11, 2014·Environment International·Mercè GaríJordi Sunyer
Mar 19, 2014·The Science of the Total Environment·Gyuyeon ChoiJeongim Park
Sep 14, 2010·The Science of the Total Environment·Sabrina LlopJoan O Grimalt
Sep 22, 2015·Analytica Chimica Acta·Vicent YusaMarta Roca
Aug 27, 2013·The Science of the Total Environment·Mikel BasterrecheaUNKNOWN INMA project
Oct 22, 2016·Environment International·Yan ZhaoYunhui Zhang
Jan 1, 2014·International Scholarly Research Notices·Mohamed Abou-Elwafa Abdallah
Aug 12, 2016·Fertility and Sterility·Aolin WangTracey J Woodruff

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