Integrated analysis of the differential cellular and EBV miRNA expression profiles in microdissected nasopharyngeal carcinoma and non-cancerous nasopharyngeal tissues

Oncology Reports
Xun-Xun WanZhi-Qiang Xiao

Abstract

Nasopharyngeal carcinoma (NPC) is commonly diagnosed in southern Asia. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. Increasing evidence suggests that the dysregulation of miRNAs promotes NPC tumorigenesis. Epstein-Barr virus (EBV) infection and EBV-encoded miRNAs are also associated with the development of NPC. However, it is unclear how cellular and EBV miRNAs jointly regulate target genes and signaling pathways in NPC. In the present study, we analyzed the differential cellular and EBV miRNA expression profiles in 20 pooled NPC tissues using microarrays. We found that 19 cellular miRNAs and 9 EBV miRNAs were upregulated and 31 cellular miRNAs were downregulated in NPC tissues. Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that the 19 upregulated miRNAs target mainly the p53 signaling pathway in cancer, whereas the downregulated miRNAs regulate pathways related to cancer, focal adhesion and Erb, and MAPK signaling. In contrast, the upregulated EBV miRNAs target primarily the TGF-β and Wnt signaling pathways. Data also suggested that cellular miR-34b, miR-34c, miR-18a, miR‑200a/b, miR-449a, miR-31 and let-7 may be dysreg...Continue Reading

References

Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Jul 28, 2004·Trends in Microbiology·Pierre BussonMarilys Corbex
Sep 17, 2004·Nature·Victor Ambros
Jun 10, 2005·Nature·Jun LuTodd R Golub
Jun 14, 2005·Lancet·William I Wei, Jonathan S T Sham
Jul 13, 2005·Cell·Carlo M Croce, George A Calin
Oct 28, 2005·The New England Journal of Medicine·Chang-Zheng Chen
Mar 15, 2006·Cancer Cell·Nozomu YanaiharaCurtis C Harris
Aug 1, 2006·Nature Genetics·Michael DewsAndrei Thomas-Tikhonenko
May 18, 2007·Annual Review of Cell and Developmental Biology·Natascha Bushati, Stephen M Cohen
Jun 2, 2007·Molecular Cell·Tsung-Cheng ChangJoshua T Mendell
Aug 19, 2007·Cancer Research·Charles D JohnsonFrank J Slack
Oct 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Angela Kwok Fung LoS Diane Hayward
Dec 13, 2007·Nucleic Acids Research·Stephanie BarthFriedrich A Grässer
Jan 29, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ai-Lan ChengZhi-Qiang Xiao
Jan 31, 2008·JAMA : the Journal of the American Medical Association·Aaron J SchetterCurtis C Harris
Mar 5, 2008·Cancer Research·Tianli XiaWilliam J Harrington
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Srikumar SenguptaPaul Ahlquist
May 1, 2008·Head & Neck·Josephine ChouDavid M Jablons
Jun 12, 2008·JAMA : the Journal of the American Medical Association·Yujiro Kida, Yuan-Ping Han
Aug 1, 2008·Nature·Daehyun BaekDavid P Bartel
Aug 1, 2008·Nature·Matthias SelbachNikolaus Rajewsky
Aug 15, 2008·Genome Biology·Nicole CloonanSean M Grimmond
Aug 15, 2008·Nucleic Acids Research·Qin LiuXiaofei Zheng
Oct 8, 2008·The Journal of Experimental Medicine·Elizabeth Yee-Wai ChoyDong-Yan Jin
Jan 16, 2009·Journal of Virology·Jia Yun ZhuGunter Meister
Mar 19, 2009·British Journal of Cancer·H-C ChenS-J Chen
May 2, 2009·Nucleic Acids Research·M MaragkakisA G Hatzigeorgiou
Nov 3, 2009·Neoplasia : an International Journal for Oncology Research·Raymond Wai-Ming LungKa-Fai To
Jan 8, 2010·Carcinogenesis·Liming ZhangGuiyuan Li
Mar 30, 2010·Breast Cancer Research : BCR·Elizabeth O'Day, Ashish Lal
May 5, 2010·Journal of Cancer Research and Clinical Oncology·Thian-Sze WongVictor Shing-Howe To
Oct 20, 2010·The Journal of Pathology·Erik Meulmeester, Peter Ten Dijke
Dec 15, 2010·Nucleic Acids Research·Naama ElefantYael Altuvia
Jun 7, 2011·Biochimica Et Biophysica Acta·Stephanie BarthFriedrich A Grässer
Sep 9, 2011·PLoS Pathogens·Jin QiuDavid A Thorley-Lawson
Nov 24, 2011·The International Journal of Biochemistry & Cell Biology·Zijian LiYa Cao
Dec 20, 2011·Seminars in Cancer Biology·Aron R Marquitz, Nancy Raab-Traub

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Citations

Apr 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dan WangCan Guo
Aug 1, 2018·Cancers·Sharmila VelapasamyLee Fah Yap
May 14, 2020·Pathogens·Snježana Židovec LepejPetra Korać
Aug 5, 2017·Frontiers in Microbiology·Hyoji KimHironori Yoshiyama
Aug 11, 2019·Molecular Therapy. Nucleic Acids·Man WangKun Wang
Sep 5, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Tomasz KolendaKatarzyna Lamperska

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