Abstract
Lung adenocarcinoma is one of the most common cancers worldwide. However, the molecular mechanisms of lung adenocarcinoma development are still unclear. This study aimed to investigate the expression profiles of anti-lung cancer target genes in different cancer stages and to explore their functions in tumor development. Lung adenocarcinoma transcriptome and clinical data were downloaded from Genomic Data Commons Data Portal, and the anti-lung cancer target genes were retrieved from the Thomson Reuters Integrity database. The results showed that 16 anti-lung target genes were deregulated in all stages. Among these target genes, fibroblast growth factor 22 showed the most important role in transcription regulatory networks. Further analysis revealed that APC, BRIP1, and PTTG1 may regulate fibroblast growth factor 22 and subsequently influence MAPK signaling pathway, Rap1 signaling pathways, and other tumorigenic processes in all stages. Moreover, high fibroblast growth factor 22 expression leads to poor overall survival (hazard ratio = 1.55, P = .019). These findings provide valuable information for the pathological research and treatment of lung adenocarcinoma. Future studies are needed to verify these results.
References
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A F Gazdar
Oct 4, 2011·Nature Genetics·Thorunn RafnarKari Stefansson
May 16, 2012·Molecular and Cellular Biochemistry·Jia-Yu TanYa-Ling Luo
Jun 28, 2012·PloS One·Monika JaroszRichard Grose
Oct 3, 2013·Cancer Chemotherapy and Pharmacology·Michalis AlevizakosKonstantinos N Syrigos
Nov 19, 2013·Cell·Hyun Seok KimMichael A White
Feb 12, 2014·American Journal of Preventive Medicine·Alan B ZondermanMichele K Evans
Oct 11, 2014·Science·Elza C de BruinCharles Swanton
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Mar 31, 2015·International Journal of Immunopathology and Pharmacology·W-H LiZ-R Wang
Jun 13, 2015·Scientific Reports·Heonjong HanInsuk Lee
Jul 15, 2015·Nature·Julie GeorgeRoman K Thomas
Aug 25, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tu Nguyen-NgocSolange Peters
Sep 1, 2015·Journal of the National Cancer Institute·Susan J RamusSimon A Gayther
Oct 20, 2015·Oncogene·M B SchabathA A Beg
Dec 19, 2015·Experimental and Molecular Pathology·Hongxiang FengDeruo Liu
Sep 30, 2016·Oncotarget·Lisha QiWenfeng Cao
Feb 1, 2017·CA: a Cancer Journal for Clinicians·Ramón Rami-PortaValerie W Rusch
May 5, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·N S ClaytonE P Carter
May 20, 2017·Cancer Investigation·Ashraf AliRandeep Guleria
Aug 3, 2017·Scientific Reports·Guanhua RaoGiuseppe Giaccone
Aug 16, 2017·Surgical Oncology·Cristina Pérez-RamírezMiguel Ángel Calleja-Hernández
Oct 11, 2017·PloS One·Alison PearceRobyn Ward
Nov 25, 2017·Scientific Reports·Xinguo LuKeqin Li
Jan 26, 2018·Breast Cancer Research : BCR·Nana Weber-LassalleEric Hahnen
Apr 3, 2018·Journal of Thoracic Disease·Geòrgia Anguera, Margarita Majem
Citations
Sep 4, 2020·Signal Transduction and Targeted Therapy·Yangli XieLin Chen
Mar 24, 2021·Science Progress·Dahai LiuWen-Xing Li
Apr 23, 2021·Aging·Wen-Xing LiDahai Liu
May 4, 2021·Frontiers in Endocrinology·Giovanni VitaleAnnamaria Colao
Jun 3, 2021·Cells·Harriet R FergusonChiara Francavilla
Dec 16, 2021·Aging·Sheng HuYiping Wei