Integrated antibacterial and antifouling surfaces via cross-linking chitosan-g-eugenol/zwitterionic copolymer on electrospun membranes

Colloids and Surfaces. B, Biointerfaces
Zhenguang LiXiaoyan Yuan

Abstract

Integrated antibacterial and antifouling surfaces in favor of avoiding implant-related infections are necessarily required for biomaterials when they contact with the body fluid. In this work, an antibacterial and antifouling membrane was developed via cross-linking chitosan-g-eugenol and the zwitterionic copolymer poly(sulfobetaine methylacrylate-co-2-aminoethyl methacrylate) on the electrospun polycarbonate urethane substrate using genipin as a cross-linker. Antibacterial assays demonstrated that the prepared membranes had efficient antibacterial activity with 92.8 ± 2.5% and 95.2 ± 1.3% growth inhibition rates against Escherichia coli and Staphylococcus aureus, respectively. The investigations on antifouling activity and hemocompatibility of the membranes showed significant resistances to bacterial attachment, non-specific protein adsorption and platelet adhesion, and presented lower hemolytic activity and good anticoagulant activity as well. Moreover, cell culture assays indicated that the prepared membranes exerted no obvious cytotoxicity with more than 80% of relative L929 fibroblast viability. Therefore, the membranes with integrated antibacterial and antifouling properties could be potentially applied in promising indwe...Continue Reading

Citations

Mar 7, 2020·Macromolecular Rapid Communications·Wei SunHong Chen
Aug 7, 2020·Biomaterials Science·Qinggele Borjihan, Alideertu Dong
Jun 9, 2020·Frontiers in Microbiology·Musa Hassan MuhammadTianpei Huang
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Shadi HoushyarKate Fox
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·K PrzykazaR Mroczka
Mar 3, 2021·International Journal of Biological Macromolecules·Jose Luis Sanchez-SalvadorAngeles Blanco
Apr 27, 2021·Bioactive Materials·Damla KeskinPatrick van Rijn
Jun 11, 2019·ACS Applied Materials & Interfaces·Mehran GhasemlouBenu Adhikari

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