Integrated assessment of medicinal rhubarb by combination of delayed luminescence and HPLC fingerprint with emphasized on bioactivities based quality control

Chinese Medicine
Mengmeng SunMei Wang

Abstract

To promote herbal medicine depends largely on its quality. Chromatographic fingerprint is a frequent approach for quality assessment of herbs however with challenges on robust and reproducibility. To develop rapid, cheap and comprehensive measurements as complementary tools for herbal quality control are still urgently needed. Moreover, biological activities are essential for herbal quality, and should be taken into consideration with emphasized in quality control. In this research, HPLC fingerprint and delayed luminescence (DL, a rapid and systematic tool) were used to measure the rhubarb samples of multiple species. Statistics were explored to classify these rhubarb samples using data obtained from two analytic methods. In addition, DL properties were linked to specific chemical components which may reflect bioactivities of rhubarb using Spearman's rank correlation. Moreover, mice model was used to evaluate the cathartic effect between rhubarb samples stratifying by two analytic methods. We found that there was no significant difference of chemical fingerprints and DL signals among the different species of medicinal rhubarb. However, our results show a high similarity between HPLC fingerprint analysis and DL measurements in c...Continue Reading

References

May 1, 1984·Journal of Ethnopharmacology·X PeigenW Liwei
Feb 26, 2000·Lancet·V Scheid
Apr 19, 2002·Journal of Photochemistry and Photobiology. B, Biology·M W HoG Privitera
May 27, 2005·World Journal of Gastroenterology : WJG·Hong-Quan ZhangYu-Qing Wu
Jul 12, 2005·Environmental Pollution·Minna Turunen, Kirsi Latola
Mar 14, 2008·Journal of Pharmaceutical and Biomedical Analysis·Yi ChenYuan-Xing Wang
Jun 11, 2014·Journal of Photochemistry and Photobiology. B, Biology·Agata ScordinoFrancesco Musumeci
Jan 29, 2016·Luminescence : the Journal of Biological and Chemical Luminescence·Mengmeng SunJan van der Greef
Feb 24, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Shao LiuHai-Tao Liu
Jun 22, 2016·Journal of Photochemistry and Photobiology. B, Biology·Mengmeng SunShengli Wei
Mar 23, 2017·Journal of the Chinese Medical Association : JCMA·Dan-Dan ChenCheng Peng
Dec 1, 2012·Journal of Pharmaceutical Analysis·Pei WangHengchang Zang
Mar 7, 2018·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xin WuYanjun Zhang
Feb 16, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mengmeng SunMei Wang
Aug 23, 2019·Journal of Photochemistry and Photobiology. B, Biology·Rosaria GrassoAgata Scordino

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Methods Mentioned

BETA
infrared spectroscopy
PCA

Software Mentioned

DA
Similarity Evaluation System for HPLC
Similarity Evaluation System for
SPSS
Similarity Evaluation System for Chromatographic Fingerprint of
Cytoscape
OPLS
MetaboAnalyst

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