Integrated assessment of PD-L1 expression and molecular classification facilitates therapy selection and prognosis prediction in gastric cancer

Cancer Management and Research
Yeqi SunLifeng Wang

Abstract

Targeting the PD-1/PD-L1 pathway has emerged as a novel therapy for cancer. To identify rational candidates for anti-PD-1/PD-L1 immunotherapy in gastric cancer (GC), the abundance of PD-L1 expression was evaluated on a kind of biomarker-based molecular classification for shaping prognosis and treatment planning. One hundred and sixty-five GCs were classified into five subgroups using immunohistochemistry (IHC) and in situ hybridization (ISH) methods, based on a panel of seven markers (MLH1, PMS2, MSH2, MSH6, E-cadherin, P53, and Epstein-Barr virus mRNA). The expression of PD-L1 in GC tissues was analyzed immunohistochemically. The five categories (Epstein-Barr virus positivity, microsatellite instability, aberrant E-cadherin, aberrant P53 expression, and normal P53 expression) correspond to the reported molecular subgroups for similar proportions and clinicopathologic characteristics. Survival analysis indicated that subgroups with aberrant E-cadherin expression independently predicted a worse prognosis in GC patients (HR=2.51, P=0.010). The clinical and prognostic profiles produced by this stratification in nonintestinal-type GC were distinguishable from those in intestinal-type. Although PD-L1 was not a significant prognostic...Continue Reading

Citations

Dec 15, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Junjie YinXudong Wei
Feb 14, 2021·Nature Reviews. Clinical Oncology·Deborah Blythe DoroshowFred R Hirsch
Aug 18, 2020·International Journal of Radiation Oncology, Biology, Physics·Roshal R PatelJames W Welsh

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Methods Mentioned

BETA
surgical resection
PCR

Software Mentioned

pheatmap package for R
STATA

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